Journal article
Population Pharmacokinetics and Exposure-Uric Acid Analyses After Single and Multiple Doses of ABT-639, a Calcium Channel Blocker, in Healthy Volunteers
The AAPS journal, Vol.17(2), pp.416-426
03/2015
DOI: 10.1208/s12248-014-9709-1
PMCID: PMC4365099
PMID: 25567367
Abstract
ABT-639 is a selective T-type calcium channel blocker with efficacy in a wide range of preclinical models of nociceptive and neuropathic pain. In the current first-in-human (FIH) study, the pharmacokinetics, tolerability, and safety of ABT-639 after single- (up to 170 mg) and multiple doses (up to 160 mg BID) were evaluated in healthy volunteers in a randomized, double-blinded, placebo-controlled manner. ABT-639 demonstrated acceptable safety and pharmacokinetic profiles in human. Results from assessment of the routine laboratory variables showed an unexpected statistically significant and clinically relevant decrease in blood uric acid with the increase in ABT-639 dose, which is possibly due to inhibition in URAT1 transporter. Pharmacokinetic/pharmacodynamic models were constructed to characterize the relationship between ABT-639 exposure and uric acid response. The final model was a mechanism-based indirect response pharmacodynamic model with the stimulation of uric acid elimination by ABT-639. The model estimated
K
in
values in males and females were 10.2 and 7.13 μmol/h, respectively. The model estimated
K
out
was 0.033 1/h. ABT-639 concentration that can produce 50% stimulation in uric acid elimination was estimated to be 8,070 ng/mL. Based on the final model, further simulations were conducted to predict the effect of ABT-639 on uric acid in gout patients. The simulation results indicated that, if the urate-lowering response to ABT-639 in gout patients is similar to that in healthy subjects, ABT-639 BID doses of 140 mg or higher would be expected to provide clinically meaningful lowering of blood uric acid levels below the 380 μmol/L solubility limit of monosodium urate.
Details
- Title: Subtitle
- Population Pharmacokinetics and Exposure-Uric Acid Analyses After Single and Multiple Doses of ABT-639, a Calcium Channel Blocker, in Healthy Volunteers
- Creators
- Guohua An - Department of Clinical Pharmacology and Pharmacometrics, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064 USAWei Liu - AbbVieW. Rachel Duan - Pain Care, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064 USAWolfram Nothaft - Pain Care, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064 USAWalid Awni - Department of Clinical Pharmacology and Pharmacometrics, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064 USASandeep Dutta - Department of Clinical Pharmacology and Pharmacometrics, Research and Development, AbbVie, 1 North Waukegan Road, North Chicago, Illinois 60064 USA
- Resource Type
- Journal article
- Publication Details
- The AAPS journal, Vol.17(2), pp.416-426
- Publisher
- Springer US; Boston
- DOI
- 10.1208/s12248-014-9709-1
- PMID
- 25567367
- PMCID
- PMC4365099
- ISSN
- 1550-7416
- eISSN
- 1550-7416
- Language
- English
- Date published
- 03/2015
- Academic Unit
- Pharmaceutical Sciences and Experimental Therapeutics
- Record Identifier
- 9984065690102771
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