Journal article
Population-based Assessment of Hospitalizations for Neutropenia from Chemotherapy in Older Adults with Non-Hodgkin’s Lymphoma (United States)
Cancer causes & control, Vol.17(5), pp.647-654
06/2006
DOI: 10.1007/s10552-005-0502-4
PMID: 16633911
Abstract
To study neutropenia hospitalization (NH) incidence and risk factors in a population-based sample of older adults with non-Hodgkin’s lymphoma (NHL) and evaluate the validity of inferences from Surveillance, Epidemiology and End Results (SEER)-Medicare linked databases.NHL cases receiving first-course chemotherapy were identified from Iowa SEER-Medicare. Survival methods evaluated NH risk factors. Medical record and Medicare claims data on chemotherapy and NH were compared.Of 761 subjects, 165 (21.7%, 95% CI: 18.8, 24.6) were hospitalized for neutropenia. Of those hospitalized, 41% were hospitalized in cycle 1 and 22% in cycle 2. Significant multivariable risk factors for NH were diffuse large cell histology, renal disease, Charlson comorbidity index, and anthracycline chemotherapy but not patient age. Medicare and medical records agreed on month of chemotherapy initiation 95% of the time and chemotherapy type 95% of the time. ICD-9 code 288.0 sensitivity for NH was 80%.Neutropenia hospitalizations were common in the first 2 chemotherapy cycles, especially among older adults with comorbidity. Findings conflict with a prior medical records study in which age was a risk factor for NH and dose intensity a negative confounder. Valid inferences about age effects on chemotherapy toxicity require more clinical detail than is available in administrative data.
Details
- Title: Subtitle
- Population-based Assessment of Hospitalizations for Neutropenia from Chemotherapy in Older Adults with Non-Hodgkin’s Lymphoma (United States)
- Creators
- Shari Chen-Hardee - Health Effectiveness Research Center The University of Iowa Iowa City IA USAElizabeth Chrischilles - Holden Comprehensive Cancer Center The University of Iowa Iowa City IA USAMargaret Voelker - Health Effectiveness Research Center The University of Iowa Iowa City IA USAJohn Brooks - College of Pharmacy The University of Iowa Iowa City IA USAShane Scott - College of Medicine The University of Iowa Iowa City IA USABrian Link - College of Medicine The University of Iowa Iowa City IA USADavid Delgado - Amgen Inc. Thousand Oaks CA USA
- Resource Type
- Journal article
- Publication Details
- Cancer causes & control, Vol.17(5), pp.647-654
- Publisher
- Kluwer Academic Publishers
- DOI
- 10.1007/s10552-005-0502-4
- PMID
- 16633911
- ISSN
- 0957-5243
- eISSN
- 1573-7225
- Language
- English
- Date published
- 06/2006
- Academic Unit
- Pharmacy; Hematology, Oncology, and Blood & Marrow Transplantation; Epidemiology; Internal Medicine
- Record Identifier
- 9984094323702771
Metrics
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