Journal article
Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation
Birth defects research. A Clinical and molecular teratology, Vol.106(11), pp.972-982
11/2016
DOI: 10.1002/bdra.23587
PMCID: PMC5485911
PMID: 27891783
Abstract
Congenital microcephaly has been linked to maternal Zika virus infection. However, ascertaining infants diagnosed with microcephaly can be challenging.
Thirty birth defects surveillance programs provided data on infants diagnosed with microcephaly born 2009 to 2013. The pooled prevalence of microcephaly per 10,000 live births was estimated overall and by maternal/infant characteristics. Variation in prevalence was examined across case finding methods. Nine programs provided data on head circumference and conditions potentially contributing to microcephaly.
The pooled prevalence of microcephaly was 8.7 per 10,000 live births. Median prevalence (per 10,000 live births) was similar among programs using active (6.7) and passive (6.6) methods; the interdecile range of prevalence estimates was wider among programs using passive methods for all race/ethnicity categories except Hispanic. Prevalence (per 10,000 live births) was lowest among non-Hispanic Whites (6.5) and highest among non-Hispanic Blacks and Hispanics (11.2 and 11.9, respectively); estimates followed a U-shaped distribution by maternal age with the highest prevalence among mothers <20 years (11.5) and ≥40 years (13.2). For gestational age and birth weight, the highest prevalence was among infants <32 weeks gestation and infants <1500 gm. Case definitions varied; 41.8% of cases had an HC ≥ the 10
percentile for sex and gestational age.
Differences in methods, population distribution of maternal/infant characteristics, and case definitions for microcephaly can contribute to the wide range of observed prevalence estimates across individual birth defects surveillance programs. Addressing these factors in the setting of Zika virus infection can improve the quality of prevalence estimates. Birth Defects Research (Part A) 106:972-982, 2016. © 2016 Wiley Periodicals, Inc.
Details
- Title: Subtitle
- Population-based microcephaly surveillance in the United States, 2009 to 2013: An analysis of potential sources of variation
- Creators
- Janet D Cragan - Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaJennifer L Isenburg - Carter Consulting Inc., Atlanta, GeorgiaSamantha E Parker - Department of Epidemiology, Boston University School of Public Health, Boston, MassachusettsC J Alverson - Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaRobert E Meyer - State Center for Health Statistics, N.C. Division of Public Health, Raleigh, North CarolinaErin B Stallings - Carter Consulting Inc., Atlanta, GeorgiaRussell S Kirby - Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FloridaPhilip J Lupo - Section of Hematology-Oncology, Department of Pediatrics, Baylor College of Medicine, Houston, TexasJennifer S Liu - Leidos Holdings, Inc., Reston, VirginiaAmanda Seagroves - Carter Consulting Inc., Atlanta, GeorgiaMary K Ethen - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasSook Ja Cho - Division of Community and Family Health, Minnesota Department of Health, St. Paul, MinnesotaMaryAnn Evans - Oregon Birth Anomalies Surveillance System, Oregon Public Health Division, Portland, OregonRebecca F Liberman - Center for Birth Defects Research and Prevention, Massachusetts Department of Public Health, Boston, MassachusettsJane Fornoff - Division of Epidemiologic Studies, Illinois Department of Public Health, Springfield, IllinoisMarilyn L Browne - New York State Department of Health, Albany, New YorkRachel E Rutkowski - Department of Community and Family Health, College of Public Health, University of South Florida, Tampa, FloridaAmy E Nance - Utah Birth Defect Network, Division of Family Health and Preparedness, Utah Department of Health, Salt Lake City, UtahMarlene Anderka - National Birth Defects Prevention Network, Houston, TexasDeborah J Fox - New York State Department of Health, Albany, New YorkAmy Steele - Utah Birth Defect Network, Division of Family Health and Preparedness, Utah Department of Health, Salt Lake City, UtahGlenn Copeland - Division for Vital Records and Health Statistics, Michigan Department of Health and Human Services, Lansing, MichiganPaul A Romitti - College of Public Health, University of Iowa, Iowa City, IowaCara T Mai - Division of Congenital and Developmental Disorders, National Center on Birth Defects and Developmental Disabilities, Centers for Disease Control and Prevention, Atlanta, GeorgiaNational Birth Defects Prevention Network
- Resource Type
- Journal article
- Publication Details
- Birth defects research. A Clinical and molecular teratology, Vol.106(11), pp.972-982
- DOI
- 10.1002/bdra.23587
- PMID
- 27891783
- PMCID
- PMC5485911
- NLM abbreviation
- Birth Defects Res A Clin Mol Teratol
- ISSN
- 1542-0752
- eISSN
- 1542-0760
- Publisher
- United States
- Grant note
- CC999999 / Intramural CDC HHS U01 DD001035 / NCBDD CDC HHS
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9983995010202771
Metrics
27 Record Views