Journal article
Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study
British journal of clinical pharmacology, Vol.66(5), pp.629-639
11/2008
DOI: 10.1111/j.1365-2125.2008.03276.x
PMCID: PMC2661978
PMID: 18771484
Abstract
WHAT IS ALREADY KNOWN ABOUT THIS SUBJECT
Risperidone metabolism is affected by blocking CYP2D6 and CYP3A4 (in CYP2D6 poor metabolizers) metabolizing enzymes.
Age affects risperidone disposition and renal function affects elimination of 9-hydroxy-risperidone (primary active metabolite).
WHAT THIS STUDY ADDS
The detection of a systematic shift in estimated apparent clearance in the African-American population (it is not clear if there are biological or sociological contributors), and a shift in the clearance rate of risperidone based on concomitant administration of paroxetine, manifested as a change in assignment to a different metabolizer subpopulation group that may be primarily related to CYP2D6 metabolizer status.
The study shows an age-related decrement in 9-hydroxy-risperidone clearance across a wide range of ages.
Information on the nature of the pharmacokinetic variability with risperidone when used in a typical clinical patient population.
There are significant differences in the absolute values as well as the assignment to metabolizer status across race and concomitant paroxetine administration.
Details
- Title: Subtitle
- Population pharmacokinetic analysis for risperidone using highly sparse sampling measurements from the CATIE study
- Creators
- Yan FengBruce G Pollock - Centre for Addiction and Mental Health, University of TorontoKim Coley - Department of Pharmacy and Therapeutics, School of Pharmacy, University of PittsburghStephen MarderDel Miller - Department of Psychiatry, College of Medicine, University of IowaMargaret Kirshner - Department of Psychiatry, School of MedicineManickam AravagiriLon Schneider - Keck School of Medicine, University of Southern CaliforniaRobert R Bies - Centre for Addiction and Mental Health, University of Toronto
- Resource Type
- Journal article
- Publication Details
- British journal of clinical pharmacology, Vol.66(5), pp.629-639
- Publisher
- Blackwell Science Inc
- DOI
- 10.1111/j.1365-2125.2008.03276.x
- PMID
- 18771484
- PMCID
- PMC2661978
- ISSN
- 0306-5251
- eISSN
- 1365-2125
- Language
- English
- Date published
- 11/2008
- Academic Unit
- Psychiatry
- Record Identifier
- 9984003919802771
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