Journal article
Porcine Vagina Ex Vivo as a Model for Studying Permeability and Pathogenesis in Mucosa
Journal of pharmaceutical sciences, Vol.97(1), pp.9-21
01/2008
DOI: 10.1002/jps.21077
PMID: 17721937
Abstract
The vaginal mucosa is commonly exposed to a variety of topical agents, including chemical contraceptives, drugs for the treatment of specific pathological conditions, and pathogenic microorganisms. In vitro models can provide important information regarding the penetration and efficacy of topical compounds as well as the pathogenesis of various diseases such a menstrual toxic shock syndrome. Realistic and reproducible test systems are important if new agents are to fulfill their therapeutic potential in human populations. The selection of appropriate animal species and tissue and the use of valid in vitro systems can avoid many of the shortcomings of current animal and cell culture test systems. This review provides information about the factors that should be considered when selecting the best model to study the permeability of the human vagina. The characteristics of an ex vivo porcine model are explored and the validity of this model is demonstrated in terms of its histology, ultrastructure and composition and organization of the permeability barrier; data indicate excellent correlation of permeability and tissue response between human and porcine vaginal tissue. © 2007 Wiley‐Liss, Inc. and the American Pharmacists Association J Pharm Sci 97:9–21, 2008
Details
- Title: Subtitle
- Porcine Vagina Ex Vivo as a Model for Studying Permeability and Pathogenesis in Mucosa
- Creators
- Christopher A Squier - Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 54222Mary J Mantz - Dows Institute for Dental Research, College of Dentistry, The University of Iowa, Iowa City, Iowa 54222Patrick M Schlievert - Department of Microbiology, University of Minnesota, Minneapolis, Minnesota 55455Catherine C Davis - Product Safety & Regulatory Affairs, FemCare, The Procter & Gamble Company, Cincinnati, Ohio 45224
- Resource Type
- Journal article
- Publication Details
- Journal of pharmaceutical sciences, Vol.97(1), pp.9-21
- DOI
- 10.1002/jps.21077
- PMID
- 17721937
- NLM abbreviation
- J Pharm Sci
- ISSN
- 0022-3549
- eISSN
- 1520-6017
- Publisher
- Elsevier Inc
- Language
- English
- Date published
- 01/2008
- Academic Unit
- Oral Pathology, Radiology and Medicine; Microbiology and Immunology; International Programs; Internal Medicine
- Record Identifier
- 9984001143702771
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