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Porcine cancer models for translational oncology
Journal article   Open access

Porcine cancer models for translational oncology

Jessica C Sieren, Dawn Quelle, David K Meyerholz and Christopher S Rogers
Molecular & cellular oncology, Vol.1(4), pp.e969626-e969626
12/08/2014
DOI: 10.4161/23723548.2014.969626
PMCID: PMC4905218
PMID: 27308376
url
https://doi.org/10.4161/23723548.2014.969626View
Published (Version of record) Open Access

Abstract

Large-animal cancer models are needed to advance the development of innovative and clinically applicable tumor diagnostic, therapeutic, and monitoring technologies. We developed a genetically modified porcine model of cancer based on a TP53 mutation, and established its utility for tracking tumorigenesis in vivo through non-invasive clinical imaging approaches.
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