Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients

José Hugo Mendes Luz; Paula Mendes Luz; Tiago Bilhim; Henrique Salas Martin; Hugo Rodrigues Gouveia; Élia Coimbra; Filipe Veloso Gomes; Roberto Romulo Souza; Igor Murad Faria; Tiago Nepomuceno de Miranda

doi:10.1186/s40644-017-0127-3

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Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients

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Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients

José Hugo Mendes Luz, Paula Mendes Luz, Tiago Bilhim, Henrique Salas Martin, Hugo Rodrigues Gouveia, Élia Coimbra, Filipe Veloso Gomes, Roberto Romulo Souza, Igor Murad Faria and Tiago Nepomuceno de Miranda

Cancer imaging, Vol.17(1), 25

09/20/2017

DOI: 10.1186/s40644-017-0127-3

PMID: 28931429

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Abstract

Purpose To evaluate the efficacy of portal vein embolization (PVE) with n-Butyl-cyanoacrylate (NBCA) through an ipsilateral approach before major hepatectomy. Secondary end-points were PVE safety, liver resection and patient outcome. Methods Over a 5-year period 50 non-cirrhotic consecutive patients were included with primary or secondary liver cancer treatable by hepatectomy with a liver remnant (FLR) volume less than 25% or less than 40% in diseased livers. Results There were 37 men and 13 women with a mean age of 57 years. Colorectal liver metastases were the most frequent tumor and patients were previously exposed to chemotherapy. FLR increased from 422 ml to 629 ml (P < 0.001) after PVE, corresponding to anincrease of 52%. The FLR ratio increased from 29.6% to 42.3% (P < 0.001). Kinetic growth rate was 2.98%/week. A negative association was observed between increase in the FLR and FLR ratio and FLR volume before PVE (P = 0.002). In 31 patients hepatectomy was accomplished and only one patient presented with liver insufficiency within 30 days after surgery. Conclusions PVE with NBCA through an ipsilateral puncture is effective before major hepatectomy. Meticulous attention is needed especially near the end of the embolization procedure to avoid complications.

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Title: Subtitle: Portal vein embolization with n-butyl-cyanoacrylate through an ipsilateral approach before major hepatectomy: single center analysis of 50 consecutive patients
Creators: José Hugo Mendes Luz - Instituto Nacional de Câncer - INCA
Paula Mendes Luz - Fundação Oswaldo Cruz
Tiago Bilhim - Hospital Curry Cabral
Henrique Salas Martin - Instituto Nacional de Câncer - INCA
Hugo Rodrigues Gouveia - Instituto Nacional de Câncer - INCA
Élia Coimbra - Hospital Curry Cabral
Filipe Veloso Gomes - Hospital Curry Cabral
Roberto Romulo Souza - Praça Cruz Vermelha 23, Centro, Rio de Janeiro, CEP 20230-130 Brazil
Igor Murad Faria - Instituto Nacional de Câncer - INCA
Tiago Nepomuceno de Miranda - Instituto Nacional de Câncer - INCA
Resource Type: Journal article
Publication Details: Cancer imaging, Vol.17(1), 25
DOI: 10.1186/s40644-017-0127-3
PMID: 28931429
NLM abbreviation: Cancer Imaging
ISSN: 1740-5025
eISSN: 1470-7330
Publisher: BioMed Central
Language: English
Date published: 09/20/2017
Academic Unit: Radiology
Record Identifier: 9985178657202771

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