Positive Affect and Well-Being in Huntington's Disease Moderates the Association Between Functional Impairment and HRQOL Outcomes

Rebecca E Ready; Nicholas R Boileau; Stacey K Barton; Jin-Shei Lai; Michael K McCormack; David Cella; Nora E Fritz; Jane S Paulsen; Noelle E Carlozzi

doi:10.3233/JHD-180341

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Positive Affect and Well-Being in Huntington's Disease Moderates the Association Between Functional Impairment and HRQOL Outcomes

Journal article

Peer reviewed

Positive Affect and Well-Being in Huntington's Disease Moderates the Association Between Functional Impairment and HRQOL Outcomes

Rebecca E Ready, Nicholas R Boileau, Stacey K Barton, Jin-Shei Lai, Michael K McCormack, David Cella, Nora E Fritz, Jane S Paulsen and Noelle E Carlozzi

Journal of Huntington's disease, Vol.8(2), pp.221-232

2019

DOI: 10.3233/JHD-180341

PMCID: PMC7008959

PMID: 31045519

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https://www.ncbi.nlm.nih.gov/pmc/articles/7008959View

Open Access

Abstract

Positive affect is associated with resiliency and beneficial health outcomes, but little is known about associations between positive affect and health-related quality of life (HRQOL) in Huntington's disease (HD). This longitudinal study determined the association between positive affect and several HRQOL outcomes in persons with HD. Functional status was examined as a moderator of the association between positive affect and HRQOL. Participants, with premanifest (i.e., genetically at risk but no clinical diagnosis, n = 50) and manifest HD (early-stage n = 171; late-stage n = 101), completed a measure of positive affect and well-being and several HRQOL measures at baseline, 12-, and 24-month follow-ups. UHDRS Functional Assessment scale indicated functional status. Positive affect was associated with better HRQOL for persons with premanifest and manifest HD over the 24-month time frame. These associations were moderated by functional status. For persons with higher functional status, positive affect was associated with better HRQOL, including less depression, lower anxiety, less anger, better social role satisfaction, better executive functions, greater upper extremity function, less dyscontrol, and less concern with death and dying. For persons with lower functional status, positive affect was not associated with HRQOL. Positive affect predicted better self-reported HRQOL over a 24-month period in persons with premanifest and manifest HD, particularly when participnats had better functional status. Interventions to enhance positive affect in HD may have beneficial effects on HRQOL.

Disability Evaluation

Humans

Middle Aged

Huntington Disease - psychology

Adult

Female

Male

Quality of Life - psychology

Affect

Longitudinal Studies

Details

Title: Subtitle: Positive Affect and Well-Being in Huntington's Disease Moderates the Association Between Functional Impairment and HRQOL Outcomes
Creators: Rebecca E Ready - Department of Psychological and Brain Sciences, University of Massachusetts, Amherst, MA, USA
Nicholas R Boileau - Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA
Stacey K Barton - Department of Neurology, Washington University School of Medicine, St. Louis, MO, USA
Jin-Shei Lai - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Michael K McCormack - Department of Pathology, Rowan-SOM, Stratford, NJ
David Cella - Department of Medical Social Sciences, Northwestern University Feinberg School of Medicine, Chicago, IL, USA
Nora E Fritz - Physical Therapy Program, Wayne State University, Detroit, MI, USA
Jane S Paulsen - Departments of Neurology, Psychiatry, and Psychological and Brain Sciences, University of Iowa, Iowa City, IA, USA
Noelle E Carlozzi - Department of Physical Medicine and Rehabilitation, University of Michigan, Ann Arbor, MI, USA
Resource Type: Journal article
Publication Details: Journal of Huntington's disease, Vol.8(2), pp.221-232
DOI: 10.3233/JHD-180341
PMID: 31045519
PMCID: PMC7008959
NLM abbreviation: J Huntingtons Dis
ISSN: 1879-6397
eISSN: 1879-6400
Grant note: UL1 TR000433 / NCATS NIH HHS R01 NS040068 / NINDS NIH HHS R01 NS077946 / NINDS NIH HHS
Language: English
Date published: 2019
Academic Unit: Psychiatry; Psychological and Brain Sciences
Record Identifier: 9984083875102771

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4 Times Cited - Web of Science