Positive psychosocial factors and NKT cells in ovarian cancer patients

Donald M Lamkin; Susan K Lutgendorf; Stephanie McGinn; Minh Dao; Heena Maiseri; Koen DeGeest; Anil K Sood; David M Lubaroff

doi:10.1016/j.bbi.2007.06.005

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Positive psychosocial factors and NKT cells in ovarian cancer patients

Journal article

Open access

Peer reviewed

Positive psychosocial factors and NKT cells in ovarian cancer patients

Donald M Lamkin, Susan K Lutgendorf, Stephanie McGinn, Minh Dao, Heena Maiseri, Koen DeGeest, Anil K Sood and David M Lubaroff

Brain, behavior, and immunity, Vol.22(1), pp.65-73

2008

DOI: 10.1016/j.bbi.2007.06.005

PMCID: PMC2964139

PMID: 17643954

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http://doi.org/10.1016/j.bbi.2007.06.005View

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Abstract

Psychosocial factors are known to be associated with properties of both NK cells and T cells in cancer patients. Less is known about the relationship between psychosocial factors and NKT cells, a rare group of lymphocytes that have known relevance for tumor control. We examined four psychosocial factors and percentage and number of CD3 +CD56 + NKT cells, CD3 −CD56 + NK cells, and CD3 +CD56 − T cells in peripheral blood lymphocytes (PBL), ascites, and tumor of 35 ovarian cancer patients and 28 patients with benign pelvic masses. Patients awaiting surgery for a suspected cancerous mass completed questionnaires and gave a pre-surgical blood sample. Ascites and tumor were taken during surgery. After lymphocyte isolation, subpopulations were analyzed by flow cytometry. Benign and cancer patients did not differ on PBL subpopulations. Among cancer patients, NKT cell percentage was significantly higher in tumor and ascites than in PBL; T cell percentage was significantly higher in PBL than tumor. NKT, NK, and T cell number were significantly higher in peripheral blood than in ascites. Positive reframing was related to significantly higher NKT cell percentage and number in PBL. Social support was related to significantly higher NKT cell percentage in tumor. Vigor was related to significantly higher NKT cell percentage in PBL. Total mood disturbance was not related to NKT cell percentage or number. No significant relationships were found between psychosocial factors and NK cell percentage and number and T cell percentage and number. Given the anti-tumor activity of CD3 +CD56 + cells, these relationships may have relevance for cancer control.

Psychoneuroimmunology

NK cells

NKT cells

Vigor

Distress

Coping

T cells

Social support

Details

Title: Subtitle: Positive psychosocial factors and NKT cells in ovarian cancer patients
Creators: Donald M Lamkin - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Susan K Lutgendorf - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Stephanie McGinn - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Minh Dao - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Heena Maiseri - Department of Psychology, University of Iowa, E11 Seashore Hall, Iowa City, IA 52242, USA
Koen DeGeest - Department of Obstetrics and Gynecology, Division of Gynecologic Oncology, University of Iowa, Iowa City, IA, USA
Anil K Sood - Departments of Gynecologic Oncology and Cancer Biology, University of Texas M.D. Anderson Cancer Center, Houston, TX, USA
David M Lubaroff - University of Iowa Holden Comprehensive Cancer Center, Iowa City, IA, USA
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.22(1), pp.65-73
DOI: 10.1016/j.bbi.2007.06.005
PMID: 17643954
PMCID: PMC2964139
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Elsevier Inc
Language: English
Date published: 2008
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984065877802771

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