Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function

Stanley Berent; Bruno Giordani; Shirley Lehtinen; Dorene Markel; John B Penney; H. A Buchtel; Simon Starosta‐Rubinstein; Richard Hichwa; Anne B Young

doi:10.1002/ana.410230603

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Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function

Journal article

Peer reviewed

Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function

Stanley Berent, Bruno Giordani, Shirley Lehtinen, Dorene Markel, John B Penney, H. A Buchtel, Simon Starosta‐Rubinstein, Richard Hichwa and Anne B Young

Annals of neurology, Vol.23(6), pp.541-546

06/1988

DOI: 10.1002/ana.410230603

PMID: 2970247

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Abstract

Fifteen drug‐free patients with early to mid‐stage Huntington's disease (HD) were evaluated with positron emission tomographic (PET) scans of 18F‐2‐fluro‐2‐deoxy‐D‐glucose uptake and quantitative measures of neurological function, learning, memory, and general intelligence. In comparison with a group of normal volunteers, the HD patients showed lower metabolism in both caudate (p < 0.001) and putamen (p < 0.001) on PET scans. A significant and positive relationship was found between neuropsychological measures of verbal learning and memory and caudate metabolism in the patient group but not in the normal group. Visual‐spatial learning did not reflect a similar pattern, but performance intelligence quotient was positively related to both caudate and putamen metabolism in the HD group. Vocabulary level was unrelated to either brain structure. Discussion focuses on these and other observed brain‐behaviour relationships and on the implications of these findings for general behaviors such as those involved in coping and adaptation.

Details

Title: Subtitle: Positron emission tomographic scan investigations of Huntington's disease: Cerebral metabolic correlates of cognitive function
Creators: Stanley Berent
Bruno Giordani
Shirley Lehtinen
Dorene Markel
John B Penney
H. A Buchtel
Simon Starosta‐Rubinstein
Richard Hichwa
Anne B Young
Resource Type: Journal article
Publication Details: Annals of neurology, Vol.23(6), pp.541-546
DOI: 10.1002/ana.410230603
PMID: 2970247
NLM abbreviation: Ann Neurol
ISSN: 0364-5134
eISSN: 1531-8249
Publisher: Wiley Subscription Services, Inc., A Wiley Company
Number of pages: 6
Language: English
Date published: 06/1988
Academic Unit: Radiology; Research Administration; Physics and Astronomy; Radiation Oncology
Record Identifier: 9984213445902771

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