Journal article
Possible association of a cholecystokinin promoter variant to schizophrenia
American journal of medical genetics, Vol.114(5), pp.479-482
07/08/2002
DOI: 10.1002/ajmg.10408
PMID: 12116180
Abstract
Several lines of research indicate a cholecystokinin (CCK) deficit in schizophrenia patients. A C to T substitution was found in the promoter region of the CCK gene. We investigated this promoter variant in patients with schizophrenia and geographically-matchedcontrols. The T allele was detected in 24% of the 85 schizophrenics and 16% of the 247 controls. No significant difference in the T allele frequency was found between patients and controls (chi(2) = 2.77, P > 0.1). The schizophrenia sample was analyzed further along the dimensions of positive and negative symptoms. The patients with prominent negative symptoms presented a statistically significant association to the T allele (chi(2) = 4.13, P < 0.04). However, the significance disappeared after the Bonferroni correction (P > 0.15). Since the case-control analysis may present incorrect ethnic match between cases and controls, we applied the family-based tests to verify the above findings. Both transmission disequilibrium test (TDT; chi(2) = 5.33, P < 0.025 in 12 trios) and haplotype relative risk (HRR; chi(2) = 3.844, P < 0.05 in 60 trios) indicated a significantly high transmission of T allele to schizophrenia offspring probands from their parents. While our family-based tests seem to support the CCK involvement in schizophrenia, no definite conclusion can be drawn based on such a small sample size. This preliminary finding is subjected to future investigations.
Details
- Title: Subtitle
- Possible association of a cholecystokinin promoter variant to schizophrenia
- Creators
- Zhewu Wang - Mental Health Care Line, Cincinnati VA Medical Center, Cincinnati, Ohio 45220, USA. zhewu.wang2@med.va.govThomas WassinkNancy C AndreasenRaymond R Crowe
- Resource Type
- Journal article
- Publication Details
- American journal of medical genetics, Vol.114(5), pp.479-482
- Publisher
- United States
- DOI
- 10.1002/ajmg.10408
- PMID
- 12116180
- ISSN
- 0148-7299
- eISSN
- 1096-8628
- Language
- English
- Date published
- 07/08/2002
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics; Iowa Neuroscience Institute
- Record Identifier
- 9984003436902771
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