Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity

Joanna S Kao; Jeffrey D Dawson; Jeffrey C Murray; John M Dagle; Susan K Berends; Susan B Gillen; Edward F Bell

doi:10.1111/j.1651-2227.2010.02069.x

Back

Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity

Journal article

Peer reviewed

Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity

Joanna S Kao, Jeffrey D Dawson, Jeffrey C Murray, John M Dagle, Susan K Berends, Susan B Gillen and Edward F Bell

Acta paediatrica (Oslo, Norway : 1992), Vol.100(3), pp.347-351

03/2011

DOI: 10.1111/j.1651-2227.2010.02069.x

PMCID: PMC3033479

PMID: 20969622

View Online

Abstract

To explore the association of serum bilirubin level and breast milk feeding with retinopathy of prematurity (ROP) in preterm infants. We conducted a case-control study to examine the independent and combined effects of serum bilirubin and breast milk feeding on ROP risk in infants <32 weeks gestation or with birth weight <1500 g. Cases (66 infants with ROP) were matched with controls (66 infants without ROP) based on factors known to affect ROP risk. When analysed using the paired t-test, the peak bilirubin levels were lower in ROP cases than in controls (mean 7.2 vs. 7.9 mg/dL; p = 0.045). Using conditional logistic regression, we found a negative association between highest serum bilirubin level and risk of ROP (OR = 0.82 per 1-mg/dL change in bilirubin; p = 0.06). There was no significant association between breast milk feeding and risk of ROP. Bilirubin may help to protect preterm infants against ROP.

Breast Feeding

Retinopathy of Prematurity - blood

Infant, Very Low Birth Weight

Humans

Risk Factors

Male

Gestational Age

Case-Control Studies

Bilirubin - blood

Infant, Premature

Female

Retinopathy of Prematurity - prevention & control

Retrospective Studies

Infant, Newborn

Milk, Human

Details

Title: Subtitle: Possible roles of bilirubin and breast milk in protection against retinopathy of prematurity
Creators: Joanna S Kao - Department of Pediatrics, University of Iowa, Iowa City, IA, USA
Jeffrey D Dawson
Jeffrey C Murray
John M Dagle
Susan K Berends
Susan B Gillen
Edward F Bell
Resource Type: Journal article
Publication Details: Acta paediatrica (Oslo, Norway : 1992), Vol.100(3), pp.347-351
DOI: 10.1111/j.1651-2227.2010.02069.x
PMID: 20969622
PMCID: PMC3033479
NLM abbreviation: Acta Paediatr
ISSN: 0803-5253
eISSN: 1651-2227
Publisher: Norway
Grant note: UL1 RR024979-05 / NCRR NIH HHS R01 HD052953-05 / NICHD NIH HHS R01 HD052953 / NICHD NIH HHS M01 RR000059 / NCRR NIH HHS R01 HD057192 / NICHD NIH HHS UL1 RR024979 / NCRR NIH HHS M01 RR000059-46 / NCRR NIH HHS
Language: English
Date published: 03/2011
Academic Unit: Public Health Administration; Biostatistics; Pediatric Dentistry; Craniofacial Anomalies Research Center; Nursing; Biochemistry and Molecular Biology; Neonatology; Anatomy and Cell Biology; International Programs; Stead Family Department of Pediatrics; Epidemiology; Public Policy Center (Archive); Dental Research
Record Identifier: 9983997998402771

Metrics

32 Record Views

22 Times Cited - Web of Science