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Post-TB lung function, quality of life, and radiographic findings in children
Journal article   Open access   Peer reviewed

Post-TB lung function, quality of life, and radiographic findings in children

G.L. Becker, H. Kisembo, Y. Sato, L.H. Wendt, H. Aanyu-Tukamuhebwa, R. Nantanda, J B Jackson, R.J. Blount and E. Wobudeya
IJTLD open, Vol.2(7), pp.427-433
07/09/2025
DOI: 10.5588/ijtldopen.24.0675
PMCID: PMC12248413
PMID: 40657266
url
https://doi.org/10.5588/ijtldopen.24.0675View
Published (Version of record) Open Access

Abstract

BACKGROUND The long-term effects of pulmonary TB (PTB) on pediatric lung health are poorly understood. Our objective was to assess predictors of lung function and describe health-related quality of life (QoL) and chest radiograph findings in children following PTB treatment in Kampala, Uganda. METHODS We performed a cross-sectional study of children aged 6-16 years who completed PTB treatment within the last five years compared to household controls with no history of active TB. Children underwent chest radiograph, St. George's Respiratory Questionnaire, and spirometry. Mixed-effects regression models were performed to assess predictors of lung function impairment. RESULTS We enrolled 73 children with prior TB and 49 controls. In univariate mixed-effects regression models, prior TB was associated with lower FEV1 and FVC Z-scores (p<0.05). In multivariate models, BMI-for-age Z-score predicted FVC-Z-score (p<0.001). Fibrosis and pleural thickening were common radiographic abnormalities among children with prior TB. Median SGRQ total score was higher among children with prior TB (p<0.001). CONCLUSION Children with prior TB showed reduced lung function and QoL compared to household controls. Our findings support the need for routine clinical follow-up after TB treatment.
 Tuberculosis Uganda Post-Tb Lung Disease Spirometry St. George's Respiratory Questionnaire

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