Journal article
Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory
Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(6), pp.367-370
06/2011
DOI: 10.1101/lm.2097411
PMCID: PMC3101774
PMID: 21576516
Abstract
Long-term memory formation involves covalent modification of the histone proteins that package DNA. Reducing histone acetylation by mutating histone acetyltransferases impairs long-term memory, and enhancing histone acetylation by inhibiting histone deacetylases (HDACs) improves long-term memory. Previous studies using HDAC inhibitors to enhance long-term memory have focused on the fear-conditioning task using broad-spectrum HDAC inhibitors. We have found that post-training intrahippocampal administration of the broad-spectrum HDAC inhibitor trichostatin A (TSA) or the class I HDAC-selective inhibitor MS275 enhances long-term object-location memory, supporting a role for class I HDACs in the enhancement of hippocampus-dependent memory induced by HDAC inhibition.
Details
- Title: Subtitle
- Post-training intrahippocampal inhibition of class I histone deacetylases enhances long-term object-location memory
- Creators
- Joshua D Hawk - Neuroscience Graduate Group, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USACédrick Florian - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USATed Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.18(6), pp.367-370
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.2097411
- PMID
- 21576516
- PMCID
- PMC3101774
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Alternative title
- HDAC inhibitors and object-location memory
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065823302771
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