Journal article
Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(3), pp.155-160
03/2010
DOI: 10.1101/lm.1625310
PMCID: PMC2832924
PMID: 20189960
Abstract
Research on the role of the hippocampus in object recognition memory has produced conflicting results. Previous studies have used permanent hippocampal lesions to assess the requirement for the hippocampus in the object recognition task. However, permanent hippocampal lesions may impact performance through effects on processes besides memory consolidation including acquisition, retrieval, and performance. To overcome this limitation, we used an intrahippocampal injection of the GABA agonist muscimol to reversibly inactivate the hippocampus immediately after training mice in two versions of an object recognition task. We found that the inactivation of the dorsal hippocampus after training impairs object-place recognition memory but enhances novel object recognition (NOR) memory. However, inactivation of the dorsal hippocampus after repeated exposure to the training context did not affect object recognition memory. Our findings suggest that object recognition memory formation does not require the hippocampus and, moreover, that activity in the hippocampus can interfere with the consolidation of object recognition memory when object information encoding occurs in an unfamiliar environment.
Details
- Title: Subtitle
- Post-training reversible inactivation of the hippocampus enhances novel object recognition memory
- Creators
- Ana M.M Oliveira - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USAJoshua D Hawk - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USATed Abel - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USARobbert Havekes - Department of Biology, University of Pennsylvania, Philadelphia, Pennsylvania 19104, USA
- Resource Type
- Journal article
- Publication Details
- Learning & memory (Cold Spring Harbor, N.Y.), Vol.17(3), pp.155-160
- Publisher
- Cold Spring Harbor Laboratory Press
- DOI
- 10.1101/lm.1625310
- PMID
- 20189960
- PMCID
- PMC2832924
- ISSN
- 1072-0502
- eISSN
- 1549-5485
- Alternative title
- Hippocampus and object recognition memory
- Language
- English
- Date published
- 03/2010
- Academic Unit
- Molecular Physiology and Biophysics; Psychiatry; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neuroscience and Pharmacology; Biochemistry and Molecular Biology
- Record Identifier
- 9984065733602771
Metrics
19 Record Views