Post-transcriptional regulation of type III secretion in plant and animal pathogens

Kayley H Schulmeyer; Timothy L Yahr

doi:10.1016/j.mib.2017.01.009

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Post-transcriptional regulation of type III secretion in plant and animal pathogens

Journal article

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Post-transcriptional regulation of type III secretion in plant and animal pathogens

Kayley H Schulmeyer and Timothy L Yahr

Current opinion in microbiology, Vol.36, pp.30-36

04/2017

DOI: 10.1016/j.mib.2017.01.009

PMCID: PMC5534366

PMID: 28189908

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Abstract

Type III secretion systems (T3SS) serve as a primary anti-host defense mechanism for many Gram-negative plant and animal pathogens. T3SS production is tightly controlled and activated by host-associated signals. Although transcriptional responses represent a significant component of the activation cascade, recent studies have uncovered diverse post-transcriptional mechanisms that also contribute to T3SS production. Targets for post-transcriptional control are often AraC/XylS transcription factors that promote T3SS gene expression. Commons mechanisms of post-transcriptional regulation include direct control of either the activity of AraC/XylS transcription factors by protein ligands, small molecules, or post-translational modification, or transcription factor synthesis. In the latter case, RNA-binding proteins such as Hfq, CsrA/RsmA, and components of the RNA degradosome alter mRNA stability and/or the rate of translation initiation to control transcription factor synthesis. Here we summarize post-transcriptional mechanisms that contribute to the exquisite regulation of T3SS gene expression.

Details

Title: Subtitle: Post-transcriptional regulation of type III secretion in plant and animal pathogens
Creators: Kayley H Schulmeyer - Department of Microbiology, University of Iowa, United States
Timothy L Yahr - Department of Microbiology, University of Iowa, United States. Electronic address: tim-yahr@uiowa.edu
Resource Type: Journal article
Publication Details: Current opinion in microbiology, Vol.36, pp.30-36
DOI: 10.1016/j.mib.2017.01.009
PMID: 28189908
PMCID: PMC5534366
NLM abbreviation: Curr Opin Microbiol
ISSN: 1369-5274
eISSN: 1879-0364
Publisher: England
Grant note: T32 AI007511 / NIAID NIH HHS R56 AI055042 / NIAID NIH HHS T32 GM082729 / NIGMS NIH HHS R01 AI055042 / NIAID NIH HHS R01 AI097264 / NIAID NIH HHS P30 DK054759 / NIDDK NIH HHS
Language: English
Date published: 04/2017
Academic Unit: Microbiology and Immunology
Record Identifier: 9984001133102771

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