Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease

H. P. Cathro; G. C. Bullock; H. Bonatti; Z. Meriden; S. Cook; N. Aguilera

doi:10.1111/tid.12300

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Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease

Journal article

Peer reviewed

Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease

H. P. Cathro, G. C. Bullock, H. Bonatti, Z. Meriden, S. Cook and N. Aguilera

Transplant infectious disease, Vol.16(6), pp.897-903

12/01/2014

DOI: 10.1111/tid.12300

PMID: 25298125

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Abstract

BackgroundAlthough the majority of post-transplant lymphoproliferative disorder (PTLD) cases are associated with Epstein-Barr virus (EBV), 20-42% of cases are EBV negative (EBV-N). The antigenic stimulus that drives EBV-N PTLD is unknown, but is likely heterogeneous. A common feature of PTLD, regardless of EBV status, is an abnormal polytypic lymphoplasmacytic infiltrate. Immunglobulin-G4 (IgG4) syndrome is also characterized by a polytypic lymphoplasmacytic infiltrate with a predominance of IgG4-positive (IgG4-P) plasma cells. MethodsWe investigated the possibility of an association between EBV-N PTLD and IgG4 syndrome. Of 33 evaluated PTLD cases, 9 (27%) were EBV-N. EBV-N PTLD cases showed longer transplantation-to-diagnosis times than EBV-positive cases. ResultsA single patient had a preceding benign duodenal biopsy with focally prominent IgG4-P plasma cells; however, no clinical data supported IgG4 syndrome, precluding an association between IgG4 syndrome and subsequent EBV-N PTLD in this patient. ConclusionAs none of 29 evaluable cases of PTLD (including all 9 EBV-N cases) were associated with an increase in IgG4-P plasma cells, IgG4 syndrome does not appear to play a role in the etiology of EBV-N PTLD. The significance of these findings and the current understanding of the etiology of EBV-N PTLD are discussed.

Immunology

Infectious Diseases

Life Sciences & Biomedicine

Science & Technology

Transplantation

Details

Title: Subtitle: Post-transplant lymphoproliferative disorders are not associated with IgG4 sclerosing disease
Creators: H. P. Cathro - University of Virginia
G. C. Bullock - University of Pittsburgh
H. Bonatti - University of Maryland, Baltimore
Z. Meriden - Johns Hopkins University
S. Cook - University of Virginia
N. Aguilera - University of Virginia
Resource Type: Journal article
Publication Details: Transplant infectious disease, Vol.16(6), pp.897-903
Publisher: Wiley
DOI: 10.1111/tid.12300
PMID: 25298125
ISSN: 1398-2273
eISSN: 1399-3062
Number of pages: 7
Language: English
Date published: 12/01/2014
Academic Unit: Pathology
Record Identifier: 9984697739002771

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