Journal article
Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention
Journal of orthopaedic research, Vol.29(6), pp.802-809
06/2011
DOI: 10.1002/jor.21359
PMCID: PMC3082940
PMID: 21520254
Abstract
Even with current treatments of acute joint injuries, more than 40% of people who suffer significant ligament or meniscus tears, or articular surface injuries, will develop osteoarthritis (OA). Correspondingly, 12% or more of all patients with lower extremity OA have a history of joint injury. Recent research suggests that acute joint damage that occurs at the time of an injury initiates a sequence of events that can lead to progressive articular surface damage. New molecular interventions, combined with evolving surgical methods, aim to minimize or prevent progressive tissue damage triggered by joint injury. Seizing the potential for progress in the treatment of joint injuries to forestall OA will depend on advances in (1) quantitative methods of assessing the injury severity, including both structural damage and biologic responses, (2) understanding of the pathogenesis of post-traumatic OA, taking into account potential interactions among the different tissues and the role of post-traumatic incongruity and instability, and (3) application of engineering and molecular research to develop new methods of treating injured joints. This paper highlights recent advances in understanding of the structural damage and the acute biological response following joint injury, and it identifies important directions for future research.
Details
- Title: Subtitle
- Post-traumatic osteoarthritis: improved understanding and opportunities for early intervention
- Creators
- Donald D Anderson - Department of Orthopaedics & Rehabilitation, The University of Iowa, Iowa City, Iowa 52242, USA. don-anderson@uiowa.eduSusan ChubinskayaFarshid GuilakJames A MartinTheodore R OegemaSteven A OlsonJoseph A Buckwalter
- Resource Type
- Journal article
- Publication Details
- Journal of orthopaedic research, Vol.29(6), pp.802-809
- DOI
- 10.1002/jor.21359
- PMID
- 21520254
- PMCID
- PMC3082940
- NLM abbreviation
- J Orthop Res
- ISSN
- 0736-0266
- eISSN
- 1554-527X
- Publisher
- United States
- Grant note
- P50 AR055533 / NIAMS NIH HHS P50 AR048939-01 / NIAMS NIH HHS P01 AR050245 / NIAMS NIH HHS P50 AR039239 / NIAMS NIH HHS P50 AR055533-01 / NIAMS NIH HHS R01 AG015768 / NIA NIH HHS AR48939 / NIAMS NIH HHS R24 AR046601-01 / NIAMS NIH HHS R01 AG015768-02 / NIA NIH HHS AR55533 / NIAMS NIH HHS R01 AR048182-06 / NIAMS NIH HHS AR46601 / NIAMS NIH HHS R01 AR048852-01A2 / NIAMS NIH HHS AR48182 / NIAMS NIH HHS P50 AR039239-11 / NIAMS NIH HHS R24 AR046601 / NIAMS NIH HHS AR39239 / NIAMS NIH HHS P01 AR050245-01 / NIAMS NIH HHS R01 AR048852 / NIAMS NIH HHS R01 AR046601 / NIAMS NIH HHS AG15768 / NIA NIH HHS P50 AR048939 / NIAMS NIH HHS R01 AR048182 / NIAMS NIH HHS AR50245 / NIAMS NIH HHS AR48852 / NIAMS NIH HHS
- Language
- English
- Date published
- 06/2011
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Stead Family Department of Pediatrics; Pharmaceutical Sciences and Experimental Therapeutics; Orthopedics and Rehabilitation; Industrial and Systems Engineering; Injury Prevention Research Center
- Record Identifier
- 9984040281802771
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