Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study

Victória A Muller Ewald; Jessica R Purnell; Joel E Bruss; Ercole J Barsotti; Amro S Aldine; Kurayi G Mahachi; John A Wemmie; Vincent A Magnotta; Aaron D Boes; Krystal L Parker; Jess G Fiedorowicz

doi:10.1007/s12311-022-01408-1

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Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study

Journal article

Peer reviewed

Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study

Victória A Muller Ewald, Jessica R Purnell, Joel E Bruss, Ercole J Barsotti, Amro S Aldine, Kurayi G Mahachi, John A Wemmie, Vincent A Magnotta, Aaron D Boes, Krystal L Parker, …

Cerebellum (London, England), Vol.22(3), pp.370-378

06/01/2023

DOI: 10.1007/s12311-022-01408-1

PMCID: PMC9659668

PMID: 35568792

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Abstract

Posterior fossa arachnoid cysts (PFACs) are rare congenital abnormalities observed in 0.3 to 1.7% of the population and are traditionally thought to be benign. While conducting a neuroimaging study investigating cerebellar structure in bipolar disorder, we observed a higher incidence of PFACs in bipolar patients (5 of 75; 6.6%) compared to the neuronormative control group (1 of 54; 1.8%). In this report, we detail the cases of the five patients with bipolar disorder who presented with PFACs. Additionally, we compare neuropsychiatric measures and cerebellar volumes of these patients to neuronormative controls and bipolar controls (those with bipolar disorder without neuroanatomical abnormalities). Our findings suggest that patients with bipolar disorder who also present with PFACs may have a milder symptom constellation relative to patients with bipolar disorder and no neuroanatomical abnormalities. Furthermore, our observations align with prior literature suggesting an association between PFACs and psychiatric symptoms that warrants further study. While acknowledging sample size limitations, our primary aim in the present work is to highlight a connection between PFACs and BD-associated symptoms and encourage further study of cerebellar abnormalities in psychiatry.

Arachnoid Cysts

Bipolar Disorder

Cerebellum - abnormalities

Cranial Fossa, Posterior

Humans

Magnetic Resonance Imaging - methods

Retrospective Studies

Details

Title: Subtitle: Posterior Fossa Sub-Arachnoid Cysts Observed in Patients with Bipolar Disorder: a Retrospective Cohort Study
Creators: Victória A Muller Ewald - Department of Psychiatry, The University of Iowa, 195-207 Newton Road, Iowa City, IA, 52246, USA
Jessica R Purnell - University of Iowa
Joel E Bruss - University of Iowa
Ercole J Barsotti - University of Iowa
Amro S Aldine - Louisiana State University Health Sciences Center New Orleans
Kurayi G Mahachi - University of Iowa
John A Wemmie - University of Iowa
Vincent A Magnotta - University of Iowa
Aaron D Boes - University of Iowa
Krystal L Parker - University of Iowa
Jess G Fiedorowicz - University of Ottawa
Resource Type: Journal article
Publication Details: Cerebellum (London, England), Vol.22(3), pp.370-378
DOI: 10.1007/s12311-022-01408-1
PMID: 35568792
PMCID: PMC9659668
NLM abbreviation: Cerebellum
ISSN: 1473-4222
eISSN: 1473-4230
Grant note: S10 OD025025 / NIH HHS R01 MH113325 / NIMH NIH HHS P50 HD103556 / NICHD NIH HHS R01 NS114405 / NINDS NIH HHS T32 MH019113 / NIMH NIH HHS R01 MH125838 / NIMH NIH HHS R01 MH111578 / NIMH NIH HHS R01 MH118240 / NIMH NIH HHS RO1 MH 118240 / NIMH NIH HHS
Language: English
Date published: 06/01/2023
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Neurology; Radiology; Molecular Physiology and Biophysics; Psychiatry; Stead Family Department of Pediatrics; Epidemiology; Psychological and Brain Sciences; Iowa Neuroscience Institute; Neurology (Pediatrics); Neurosurgery
Record Identifier: 9984622752202771

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