Posterior pole asymmetry analysis with optical coherence tomography

L Kochendörfer; P Bauer; J Funk; M Töteberg-Harms

doi:10.1055/s-0034-1368213

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Posterior pole asymmetry analysis with optical coherence tomography

Journal article

Peer reviewed

Posterior pole asymmetry analysis with optical coherence tomography

L Kochendörfer, P Bauer, J Funk and M Töteberg-Harms

Klinische Monatsblatter fur Augenheilkunde, Vol.231(4), pp.368-373

04/01/2014

DOI: 10.1055/s-0034-1368213

PMID: 24771169

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Abstract

The aim of this study was to evaluate the reproducibility of the posterior pole asymmetry analysis (PPAA) in glaucomatous eyes and healthy controls in comparison to retinal nerve fiber layer measurements (RNFL) with spectral domain optical coherence tomography (SD-OCT). Prospectively, in a single session by one operator, three measurements were taken of the retinal thickness with the PPAA and three measurements of the RNFL with the eye-tracker function of the Heidelberg Spectralis SD-OCT. The mean intraclass correlation coefficient (ICC) and lower confidence intervals (in parentheses) for PPAA were 0.98 (0.96) in both healthy (36 eyes) and glaucomatous eyes (26 eyes). Global coefficients of variation (COVs) were between 0.0 and 1.1% in healthy controls and between 0.0 and 1.9% in glaucoma eyes. Global ICCs for RNFL were 0.98 (0.96) in healthy controls and 0.98 (0.97) in glaucoma eyes and global COVs were between 0.0 and 6.8% in healthy controls and between 0.0 and 3.0% in glaucoma eyes. Reproducibility of the PPAA was good and exceeds that of established RNFL measurements. Thus, PPAA is an additional useful tool in management of glaucoma.

Adult

Case-Control Studies

Female

Glaucoma - pathology

Humans

Image Interpretation, Computer-Assisted - methods

Male

Middle Aged

Nerve Fibers - pathology

Prospective Studies

Reproducibility of Results

Retinal Ganglion Cells - pathology

Sensitivity and Specificity

Tomography, Optical Coherence - methods

Details

Title: Subtitle: Posterior pole asymmetry analysis with optical coherence tomography
Creators: L Kochendörfer - University Hospital of Zurich
P Bauer - Kantonsspital Winterthur
J Funk - University Hospital of Zurich
M Töteberg-Harms - UniversityHospital Zurich, Department of Ophthalmology, Zurich, Switzerland
Resource Type: Journal article
Publication Details: Klinische Monatsblatter fur Augenheilkunde, Vol.231(4), pp.368-373
DOI: 10.1055/s-0034-1368213
PMID: 24771169
ISSN: 0023-2165
eISSN: 1439-3999
Language: English
Date published: 04/01/2014
Academic Unit: Ophthalmology and Visual Sciences
Record Identifier: 9984696574902771

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