Postmeal Optogenetic Inhibition of Dorsal or Ventral Hippocampal Pyramidal Neurons Increases Future Intake

Reilly Hannapel; Janavi Ramesh; Amy Ross; Ryan T LaLumiere; Aaron G Roseberry; Marise B Parent

doi:10.1523/eneuro.0457-18.2018

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Postmeal Optogenetic Inhibition of Dorsal or Ventral Hippocampal Pyramidal Neurons Increases Future Intake

Journal article

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Postmeal Optogenetic Inhibition of Dorsal or Ventral Hippocampal Pyramidal Neurons Increases Future Intake

Reilly Hannapel, Janavi Ramesh, Amy Ross, Ryan T LaLumiere, Aaron G Roseberry and Marise B Parent

eNeuro, Vol.6(1), p.ENEURO.0457-18.2018

01/2019

DOI: 10.1523/eneuro.0457-18.2018

PMCID: PMC6348449

PMID: 30693314

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Abstract

Memory of a recently eaten meal can serve as a powerful mechanism for controlling future eating behavior because it provides a record of intake that likely outlasts most physiological signals generated by the meal. In support, impairing the encoding of a meal in humans increases the amount ingested at the next eating episode. However, the brain regions that mediate the inhibitory effects of memory on future intake are unknown. In the present study, we tested the hypothesis that dorsal hippocampal (dHC) and ventral hippocampal (vHC) glutamatergic pyramidal neurons play a critical role in the inhibition of energy intake during the postprandial period by optogenetically inhibiting these neurons at specific times relative to a meal. Male Sprague Dawley rats were given viral vectors containing CaMKIIα-eArchT3.0-eYFP or CaMKIIα-GFP and fiber optic probes into dHC of one hemisphere and vHC of the other. Compared to intake on a day in which illumination was not given, inhibition of dHC or vHC glutamatergic neurons after the end of a chow, sucrose, or saccharin meal accelerated the onset of the next meal and increased the amount consumed during that next meal when the neurons were no longer inhibited. Inhibition given during a meal did not affect the amount consumed during that meal or the next one but did hasten meal initiation. These data show that dHC and vHC glutamatergic neuronal activity during the postprandial period is critical for limiting subsequent ingestion and suggest that these neurons inhibit future intake by consolidating the memory of the preceding meal.

Neural Inhibition

Tissue Culture Techniques

Optogenetics

Rats, Sprague-Dawley

Feeding Behavior - physiology

Eating - physiology

Postprandial Period - physiology

Saccharin

Animals

Pyramidal Cells - physiology

Glutamic Acid - metabolism

Dietary Sucrose

Hippocampus - physiology

Memory - physiology

Details

Title: Subtitle: Postmeal Optogenetic Inhibition of Dorsal or Ventral Hippocampal Pyramidal Neurons Increases Future Intake
Creators: Reilly Hannapel - Neuroscience Institute, Georgia State University, Atlanta, GA 30303
Janavi Ramesh - Neuroscience Institute, Georgia State University, Atlanta, GA 30303
Amy Ross - Neuroscience Institute, Georgia State University, Atlanta, GA 30303
Ryan T LaLumiere - Department of Psychological and Brain Sciences and Iowa Neuroscience Institute, University of Iowa, Iowa City, IA 52242
Aaron G Roseberry - Department of Biology, Georgia State University, Atlanta, GA 30303
Marise B Parent - Department of Psychology, Georgia State University, Atlanta, GA 30303
Resource Type: Journal article
Publication Details: eNeuro, Vol.6(1), p.ENEURO.0457-18.2018
DOI: 10.1523/eneuro.0457-18.2018
PMID: 30693314
PMCID: PMC6348449
NLM abbreviation: eNeuro
ISSN: 2373-2822
eISSN: 2373-2822
Publisher: United States
Grant note: R01 DK114700 / NIDDK NIH HHS
Language: English
Date published: 01/2019
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute
Record Identifier: 9984002344302771

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