Journal article
Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls
Journal of Parkinson's disease, Vol.13(3), pp.333-340
01/01/2023
DOI: 10.3233/JPD-225033
PMID: 36938740
Abstract
Background:
Essential tremor (ET) is a common movement disorder in which cerebellar microscopic and volume alterations have been repeatedly reported although with disagreement between studies. However, pronounced heterogeneity was found with regard to cerebellar volume alterations.
Objective:
This study aimed to assess postmortem cerebellar volume in subjects with or without ET, as compared with subjects with multiple system atrophy (MSA), a well-established cerebellar neurodegeneration.
Methods:
Cases with ET (n = 29), MSA (n = 7), and non-demented control cases without any movement disorder (n = 22) were selected from the Arizona Study of Aging and Neurodegenerative Disorders (AZSAND), a longitudinal clinicopathological study with annual research-dedicated clinical assessments by neuropsychologists, subspecialist movement disorders, and cognitive/behavioral neurologists, with comprehensive neuropathological examinations after death. Group comparisons were controlled for common age-related neurodegenerative and cerebrovascular pathologies. Cerebellar volumes were calculated using digital images of slices taken at the time of autopsy, immediately after brain removal and before fixation.
Results:
Cerebellar volume was not reduced in ET subjects compared to controls. The two groups did not differ in terms of incidental cerebrovascular and Alzheimer’s disease neuropathology. In contrast, cerebellar volume was significantly reduced in subjects with MSA when compared to ET and control subjects.
Conclusion:
In a well-characterized cohort, postmortem cerebellar volume measurements suggest that there are no volume alterations in ET when compared to controls, in contrast to significant cerebellar atrophy in subjects with MSA.
Details
- Title: Subtitle
- Postmortem Cerebellar Volume Is Not Reduced in Essential Tremor: A Comparison with Multiple System Atrophy and Controls
- Creators
- Cécilia Tremblay - Banner Sun Health Research InstituteGeidy E. Serrano - Banner Sun Health Research InstituteNathaniel Dunckley - Banner Sun Health Research InstituteNan Zhang - Mayo Clinic in ArizonaKimberly L. Fiock - University of IowaCharles H. Adler - Mayo Clinic in ArizonaErika Driver-Dunckley - Mayo Clinic in ArizonaShyamal H. Mehta - Mayo Clinic in ArizonaHolly A. Shill - Barrow Neurological InstituteThomas G. Beach - Banner Sun Health Research Institute
- Resource Type
- Journal article
- Publication Details
- Journal of Parkinson's disease, Vol.13(3), pp.333-340
- DOI
- 10.3233/JPD-225033
- PMID
- 36938740
- ISSN
- 1877-7171
- eISSN
- 1877-718X
- Number of pages
- 8
- Grant note
- Michael J. Fox Foundation for Parkinson's Research (http://data.elsevier.com/vocabulary/SciValFunders/100000864) U24 NS072026 / National Institute of Neurological Disorders and Stroke (http://data.elsevier.com/vocabulary/SciValFunders/100000065) P30 AG19610; P30AG072980 / National Institute on Aging (http://data.elsevier.com/vocabulary/SciValFunders/100000049) 0011; 05-901; 1001; 4001 / Arizona Biomedical Research Commission (http://data.elsevier.com/vocabulary/SciValFunders/100008335) 211002 / Arizona Department of Health Services (http://data.elsevier.com/vocabulary/SciValFunders/100007306) Arizona Alzheimer’s Research Center National Institute on Aging (http://data.elsevier.com/vocabulary/SciValFunders/100000049) Arizona Biomedical Research Commission (http://data.elsevier.com/vocabulary/SciValFunders/100008335) Arizona Department of Health Services (http://data.elsevier.com/vocabulary/SciValFunders/100007306) National Institute of Neurological Disorders and Stroke (http://data.elsevier.com/vocabulary/SciValFunders/100000065)
- Language
- English
- Date published
- 01/01/2023
- Academic Unit
- Pathology
- Record Identifier
- 9985214103402771
Metrics
1 Record Views