Journal article
Postnatal cytomegalovirus infection and pulmonary vascular disease in extremely premature infants: A case series
Journal of neonatal-perinatal medicine, Vol.17(2), pp.275-284
05/16/2024
DOI: 10.3233/NPM-230078
PMID: 38728205
Abstract
Pulmonary vascular disease (PVD) is a major determinant of both morbidity and mortality in extremely low birth weight infants. It is biologically plausible that postnatal cytomegalovirus (pCMV) infection may lead to PVD in premature infants secondary to pneumonitis or via derangement of pulmonary vascular development directly through endothelial dysfunction. Uncertainty remains, however, regarding thresholds for intervention in premature infants with cardiorespiratory instability and presumed CMV infection likely secondary to the limited understanding of the natural history of the disease.
We describe four cases of premature infants with clinical and echocardiography features of PVD, in the setting of postnatally acquired CMV. All patients had atypical PVD trajectories, refractory to vasodilator treatment, which improved after initiation of CMV treatment.
We highlight the need to consider postnatally acquired CMV infection in patients with PVD non-responsive to standard pulmonary vasodilator therapies or disease severity which is out of proportion of the usual clinical trajectory. Treatment of extremely premature infants with CMV-associated PVD may have positive impact on cardiorespiratory health, although duration of therapy remains uncertain.
Details
- Title: Subtitle
- Postnatal cytomegalovirus infection and pulmonary vascular disease in extremely premature infants: A case series
- Creators
- A H Stanford - University of IowaT Chatmethakul - University of Oklahoma Health Sciences CenterD R Rios - University of IowaR E Giesinger - University of IowaB Thomas - University of IowaA R Bischoff - University of IowaL Weiner - University of IowaP J McNamara - University of Iowa
- Resource Type
- Journal article
- Publication Details
- Journal of neonatal-perinatal medicine, Vol.17(2), pp.275-284
- Publisher
- IOS PRESS; AMSTERDAM
- DOI
- 10.3233/NPM-230078
- PMID
- 38728205
- ISSN
- 1934-5798
- eISSN
- 1878-4429
- Language
- English
- Date published
- 05/16/2024
- Academic Unit
- Stead Family Department of Pediatrics; Neonatology; Infectious Disease (Pediatrics); Internal Medicine
- Record Identifier
- 9984626142002771
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