Journal article
Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy
Orthopedics (Thorofare, N.J.), Vol.19(3), pp.207-210
03/1996
PMID: 8867548
Abstract
The effect of low dose methotrexate (MTX) on postoperative complications in rheumatoid arthritis patients undergoing elective total joint arthroplasty was observed prospectively in 32 patients. Patients were assigned to discontinue MTX the week prior to and during the week of surgery (Group 1, n = 19) or to continue MTX throughout the perioperative period (Group 2, n = 13). Nineteen patients in Group 1 had 26 procedures, with no postoperative infections. Thirteen patients in Group 2 had 16 procedures, with 4 postoperative infections: 2 infected prostheses, 1 infected joint fusion, and 1 deep wound infection (P = .03). No patient had a postoperative flare of rheumatoid arthritis. Temporary discontinuation of MTX prior to joint arthroplasty appears to decrease the risk of postoperative infection.
Details
- Title: Subtitle
- Postoperative joint infections in rheumatoid arthritis patients on methotrexate therapy
- Creators
- M T Carpenter - Department of Medicine, Fitzsimons Army Medical Center, Aurora, Colo. 80045-5000, USAS G WestS A VogelgesangD E Casey Jones
- Resource Type
- Journal article
- Publication Details
- Orthopedics (Thorofare, N.J.), Vol.19(3), pp.207-210
- PMID
- 8867548
- ISSN
- 0147-7447
- eISSN
- 1938-2367
- Language
- English
- Date published
- 03/1996
- Academic Unit
- Immunology; Internal Medicine; Ophthalmology and Visual Sciences
- Record Identifier
- 9984094649002771
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