Journal article
Postoperative pulmonary complications with adjuvant regional anesthesia versus general anesthesia alone: a sub-analysis of the Perioperative Research Network study
BMC anesthesiology, Vol.22(1), pp.136-136
05/03/2022
DOI: 10.1186/s12871-022-01679-5
PMCID: PMC9063185
PMID: 35501692
Abstract
Adjuvant regional anesthesia is often selected for patients or procedures with high risk of pulmonary complications after general anesthesia. The benefit of adjuvant regional anesthesia to reduce postoperative pulmonary complications remains uncertain. In a prospective observational multicenter study, patients scheduled for non-cardiothoracic surgery with at least one postoperative pulmonary complication surprisingly received adjuvant regional anesthesia more frequently than those with no complications. We hypothesized that, after adjusting for surgical and patient complexity variables, the incidence of postoperative pulmonary complications would not be associated with adjuvant regional anesthesia.
We performed a secondary analysis of a prospective observational multicenter study including 1202 American Society of Anesthesiologists physical status 3 patients undergoing non-cardiothoracic surgery. Patients were classified as receiving either adjuvant regional anesthesia or general anesthesia alone. Predefined pulmonary complications within the first seven postoperative days were prospectively identified. Groups were compared using bivariable and multivariable hierarchical logistic regression analyses for the outcome of at least one postoperative pulmonary complication.
Adjuvant regional anesthesia was performed in 266 (22.1%) patients and not performed in 936 (77.9%). The incidence of postoperative pulmonary complications was greater in patients receiving adjuvant regional anesthesia (42.1%) than in patients without it (30.9%) (site adjusted p = 0.007), but this association was not confirmed after adjusting for covariates (adjusted OR 1.37; 95% CI, 0.83-2.25; p = 0.165).
After adjusting for surgical and patient complexity, adjuvant regional anesthesia versus general anesthesia alone was not associated with a greater incidence of postoperative pulmonary complications in this multicenter cohort of non-cardiothoracic surgery patients.
Details
- Title: Subtitle
- Postoperative pulmonary complications with adjuvant regional anesthesia versus general anesthesia alone: a sub-analysis of the Perioperative Research Network study
- Creators
- Karsten Bartels - University of Colorado DenverGyorgy Frendl - Brigham and Women's HospitalJuraj Sprung - Mayo Clinic in ArizonaToby N Weingarten - Mayo Clinic in ArizonaBalachundhar Subramaniam - Beth Israel Deaconess Medical CenterRicardo Martinez Ruiz - University of MiamiJae-Woo Lee - University of California, San FranciscoWilliam G Henderson - University of Colorado DenverAngela Moss - University of Colorado DenverAlissa Sodickson - Brigham and Women's HospitalJadelis Giquel - University of MiamiMarcos Francisco Vidal Melo - Columbia UniversityAna Fernandez-Bustamante - University of Colorado DenverPerioperative Research Network (PRN) investigators
- Contributors
- James Blum (Contributor) - University of Iowa, Anesthesia
- Resource Type
- Journal article
- Publication Details
- BMC anesthesiology, Vol.22(1), pp.136-136
- DOI
- 10.1186/s12871-022-01679-5
- PMID
- 35501692
- PMCID
- PMC9063185
- NLM abbreviation
- BMC Anesthesiol
- ISSN
- 1471-2253
- eISSN
- 1471-2253
- Grant note
- UG3 HL140177 / NHLBI NIH HHS K23 DA040923 / NIDA NIH HHS R34 HL123438 / NHLBI NIH HHS
- Language
- English
- Date published
- 05/03/2022
- Academic Unit
- Anesthesia
- Record Identifier
- 9984295960602771
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