Journal article
Postprandial exercise attenuates glucose and insulin and is associated with age, cognitive function, and extracellular/intracellular body water
Physiological reports, Vol.13(22), e70657
11/2025
DOI: 10.14814/phy2.70657
PMCID: PMC12641450
PMID: 41277758
Appears in UI Libraries Support Open Access
Abstract
Postprandial exercise attenuates glucose/insulin and is recommended for people with metabolic disease. The magnitude of the attenuation has not been directly compared in healthy older and younger people, who are active exercisers, or correlated to biomarkers associated with aging like body water ratios and cognitive function. We determined whether a dose of prescribed exercise attenuated postprandial insulin and glucose in younger and older participants; then, we determined if age, cognitive function, and extracellular to intracellular body water levels (ECW/ICW) were associated with that attenuation. Thirty-six people, 19 younger adults (seven female) and 17 older adults (nine female), had blood samples taken after a standardized meal followed by exercise or quiet sitting. Participants completed the National Institutes of Health Toolbox assessing cognitive function and had their anthropometrics assessed including ECW/ICW. Postprandial exercise decreased insulin and glucose in younger and older adults compared to postprandial sitting (p < 0.001, p = 0.003). There were strong correlations between the extent of the metabolic response after exercise and age, ECW/ICW, and cognitive function. Our results highlight that postprandial exercise reduced insulin and glucose among young and old active exercisers and this change was associated with a person's cognitive function and body water compartment ratio (ECW/ICW).
Details
- Title: Subtitle
- Postprandial exercise attenuates glucose and insulin and is associated with age, cognitive function, and extracellular/intracellular body water
- Creators
- Michael A Petrie - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAKristin A Johnson - Colorado State UniversityPatrick M McCue - University of IowaAkanksha Aggarwal - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USATristan Brown - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAKatrina Grevengoed - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAJordan Hoyman - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAAli Kallner - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAJack Klein - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAMcKenna Lloyd - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USAMichelle Patterson - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USARichard K Shields - Department of Physical Therapy and Rehabilitation Science, Carver College of Medicine, The University of Iowa, Iowa City, Iowa, USA
- Resource Type
- Journal article
- Publication Details
- Physiological reports, Vol.13(22), e70657
- DOI
- 10.14814/phy2.70657
- PMID
- 41277758
- PMCID
- PMC12641450
- NLM abbreviation
- Physiol Rep
- ISSN
- 2051-817X
- eISSN
- 2051-817X
- Publisher
- Wiley
- Grant note
- RO1HD084645 / HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD) RO1HD082109 / HHS | NIH | Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)
- Language
- English
- Date published
- 11/2025
- Academic Unit
- Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science; Injury Prevention Research Center
- Record Identifier
- 9985034938802771
Metrics
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