Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device

Katherine N Gibson-Corley; Oliver Flouty; Hiroyuki Oya; George T Gillies; Matthew A Howard

doi:10.1155/2014/989175

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Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device

Journal article

Open access

Peer reviewed

Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device

Katherine N Gibson-Corley, Oliver Flouty, Hiroyuki Oya, George T Gillies and Matthew A Howard

BioMed research international, Vol.2014, pp.989175-10

2014

DOI: 10.1155/2014/989175

PMCID: PMC3988712

PMID: 24800260

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https://doi.org/10.1155/2014/989175View

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Abstract

Spinal cord stimulation has been utilized for decades in the treatment of numerous conditions such as failed back surgery and phantom limb syndromes, arachnoiditis, cancer pain, and others. The placement of the stimulating electrode array was originally subdural but, to minimize surgical complexity and reduce the risk of certain postsurgical complications, it became exclusively epidural eventually. Here we review the relevant clinical and experimental pathologic findings, including spinal cord compression, infection, hematoma formation, cerebrospinal fluid leakage, chronic fibrosis, and stimulation-induced neurotoxicity, associated with the early approaches to subdural electrical stimulation of the central nervous system, and the spinal cord in particular. These findings may help optimize the safety and efficacy of a new approach to subdural spinal cord stimulation now under development.

Electrodes

Electric Stimulation Therapy - methods

Electric Stimulation Therapy - instrumentation

Electric Stimulation Therapy - adverse effects

Humans

Spinal Cord Compression

Spinal Cord - physiopathology

Postoperative Complications

Spinal Cord - surgery

Details

Title: Subtitle: Postsurgical pathologies associated with intradural electrical stimulation in the central nervous system: design implications for a new clinical device
Creators: Katherine N Gibson-Corley - Division of Comparative Pathology, Department of Pathology, Carver College of Medicine, University of Iowa, 500 Newton Road, 1167 ML, Iowa City, IA 52242, USA
Oliver Flouty - Department of Neurosurgery, Carver College of Medicine, University of Iowa, 500 Newton Road, 1167 ML, Iowa City, IA 52242, USA
Hiroyuki Oya - Department of Neurosurgery, Carver College of Medicine, University of Iowa, 500 Newton Road, 1167 ML, Iowa City, IA 52242, USA
George T Gillies - Department of Mechanical and Aerospace Engineering, University of Virginia, Charlottesville, VA 22904, USA
Matthew A Howard - Department of Neurosurgery, Carver College of Medicine, University of Iowa, 500 Newton Road, 1167 ML, Iowa City, IA 52242, USA
Resource Type: Journal article
Publication Details: BioMed research international, Vol.2014, pp.989175-10
DOI: 10.1155/2014/989175
PMID: 24800260
PMCID: PMC3988712
NLM abbreviation: Biomed Res Int
ISSN: 2314-6133
eISSN: 2314-6141
Publisher: United States
Language: English
Date published: 2014
Academic Unit: Neurology; Pathology; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology; Ophthalmology and Visual Sciences
Record Identifier: 9984020648702771

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