Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants

Ronald G Strauss; Donald M Mock; John A Widness; Karen Johnson; Gretchen Cress; Robert L Schmidt

doi:10.1111/j.1537-2995.2004.03393.x

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Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants

Journal article

Open access

Peer reviewed

Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants

Ronald G Strauss, Donald M Mock, John A Widness, Karen Johnson, Gretchen Cress and Robert L Schmidt

Transfusion (Philadelphia, Pa.), Vol.44(6), pp.871-876

06/2004

DOI: 10.1111/j.1537-2995.2004.03393.x

PMCID: PMC2879037

PMID: 15157254

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Abstract

BACKGROUND: The feasibility, efficacy, and safety of transfusing stored allogeneic RBCs has been demon-strated for small-volume transfusions given to infants. We measured the posttransfusion recovery and intravascular survival of allogeneic RBCs stored up to 42 days to further elucidate their efficacy. STUDY DESIGN AND METHODS: Preterm infants were transfused with 1.0 mL of biotinylated RBCs plus 15 mL per kg of unlabeled allogeneic RBCs. Posttran-sfusion infant blood samples obtained at 10 minutes, and at 1, 2, 4, 7, 10, 14, and 21 days were used to determine the 24-hour posttransfusion recovery (PTR24), mean potential life span (MPL), and time to disappearance of 50 percent of biotinylated RBCs (T50). RESULTS: No significant differences were found between allogeneic RBCs stored 1 to 21 days versus 22 to 42 days for PTR24, MPL, or T50, indicating comparable posttransfusion circulation, regardless of storage age. Although MPL and T50 values in infants using biotinylated RBCs were short, compared to those expected using chromium-labeled RBCs in adults, they agreed with results reported by others using biotinylated RBCs. CONCLUSIONS: Satisfactory posttransfusion RBC recovery and survival, measured with biotinylated RBCs, support earlier clinical trials that established the efficacy and safety of stored allogeneic RBCs for small-volume transfusions given to infants. The relatively short MPL and T50 values in some infants may underestimate true survival due to ongoing erythropoiesis and infant growth with commensurate increase in blood volume during the time of RBC survival studies. Because values in infants differ from those expected using chromium-labeled RBCs in adults, and the number of posttransfusion determinations was few, additional studies are needed to define the mechanisms involved.

Anesthesia. Intensive care medicine. Transfusions. Cell therapy and gene therapy

Biological and medical sciences

Blood. Blood and plasma substitutes. Blood products. Blood cells. Blood typing. Plasmapheresis. Apheresis

Medical sciences

Transfusions. Complications. Transfusion reactions. Cell and gene therapy

Details

Title: Subtitle: Posttransfusion 24-hour recovery and subsequent survival of allogeneic red blood cells in the bloodstream of newborn infants
Creators: Ronald G Strauss - University of Iowa
Donald M Mock - University of Iowa
John A Widness - University of Iowa
Karen Johnson - University of Iowa Hospitals and Clinics
Gretchen Cress - University of Iowa
Robert L Schmidt - University of Iowa
Resource Type: Journal article
Publication Details: Transfusion (Philadelphia, Pa.), Vol.44(6), pp.871-876
DOI: 10.1111/j.1537-2995.2004.03393.x
PMID: 15157254
PMCID: PMC2879037
NLM abbreviation: Transfusion
ISSN: 0041-1132
eISSN: 1537-2995
Publisher: Blackwell Publishing
Language: English
Date published: 06/2004
Academic Unit: Stead Family Department of Pediatrics; Pathology; Gastroenterology, Hepatology, Pancreatology, and Nutrition
Record Identifier: 9984622047202771

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