Posttransplantation lymphoproliferative disease involving the pituitary gland

Zina Meriden; Grant C. Bullock; Adam Bagg; Hugo Bonatti; John B. Cousar; M. Beatriz Lopes; Mark K. Robbins; Helen P. Cathro

doi:10.1016/j.humpath.2010.02.015

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Posttransplantation lymphoproliferative disease involving the pituitary gland

Journal article

Peer reviewed

Posttransplantation lymphoproliferative disease involving the pituitary gland

Zina Meriden, Grant C. Bullock, Adam Bagg, Hugo Bonatti, John B. Cousar, M. Beatriz Lopes, Mark K. Robbins and Helen P. Cathro

Human pathology, Vol.41(11), pp.1641-1645

11/01/2010

DOI: 10.1016/j.humpath.2010.02.015

PMID: 20656316

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Abstract

Posttransplantation lymphoproliferative disorders (PTLD) are heterogeneous lesions with variable morphology, immunophenotype, and molecular characteristics. Multiple distinct primary lesions can occur in PTLD, rarely with both B-cell and T-cell characteristics. Lesions can involve both grafted organs and other sites; however, PTLD involving the pituitary gland has not been previously reported. We describe a patient who developed Epstein-Barr virus–negative PTLD 13 years posttransplantation involving the terminal ileum and pituitary, which was simultaneously involved by a pituitary adenoma. Immunohistochemistry of the pituitary lesion showed expression of CD79a, CD3, and CD7 with clonal rearrangements of both T-cell receptor gamma chain ( TRG@) and immunoglobulin heavy chain ( IGH@) genes. The terminal ileal lesion was immunophenotypically and molecularly distinct. This is the first report of pituitary PTLD and illustrates the potentially complex nature of PTLD.

B-cell lymphoma

EBV-negative

Pituitary

Posttransplantation lymphoproliferative disorder

T-cell lymphoma

Details

Title: Subtitle: Posttransplantation lymphoproliferative disease involving the pituitary gland
Creators: Zina Meriden - University of Virginia Health System
Grant C. Bullock - University of Virginia Health System
Adam Bagg - University of Pennsylvania
Hugo Bonatti - University of Virginia Health System
John B. Cousar - University of Virginia Health System
M. Beatriz Lopes - University of Virginia Health System
Mark K. Robbins - University of Virginia Health System
Helen P. Cathro - University of Virginia Health System
Resource Type: Journal article
Publication Details: Human pathology, Vol.41(11), pp.1641-1645
Publisher: Elsevier Inc
DOI: 10.1016/j.humpath.2010.02.015
PMID: 20656316
ISSN: 0046-8177
eISSN: 1532-8392
Language: English
Date published: 11/01/2010
Academic Unit: Pathology
Record Identifier: 9984697738202771

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