Journal article
Posttraumatic osteoarthritis: from basic science to clinical implications
OTA international : the open access journal of orthopaedic trauma, Vol.6(2 Suppl), e232
05/04/2023
DOI: 10.1097/OI9.0000000000000232
PMCID: PMC10166366
PMID: 37168031
Abstract
Posttraumatic osteoarthritis (PTOA) is a subset of osteoarthritis that occurs after joint injury and is associated with degradation of articular cartilage and subchondral bone. As compared with primary osteoarthritis, PTOA occurs in a time window initiated by a traumatic event resulting in damage to layers of joint structure and alterations in joint shape. As techniques in open reduction and internal fixation continue to mature, our success in preventing posttraumatic osteoarthritis has not kept pace. Advances in research in the subchondral bone, inflammatory response, and joint mechanics continue to open our understanding of this posttraumatic process. In addition, there are possibilities emerging as biological agents to therapeutically alter the progression of PTOA.
Details
- Title: Subtitle
- Posttraumatic osteoarthritis: from basic science to clinical implications
- Creators
- Justin M. Haller - University of UtahMarjolein C H. van der Meulen - Cornell UniversitySteven Olson - Duke UniversityDonald AndersonJ. Lawrence MarshZachary Working - University of Portland
- Resource Type
- Journal article
- Publication Details
- OTA international : the open access journal of orthopaedic trauma, Vol.6(2 Suppl), e232
- DOI
- 10.1097/OI9.0000000000000232
- PMID
- 37168031
- PMCID
- PMC10166366
- NLM abbreviation
- OTA Int
- eISSN
- 2574-2167
- Publisher
- Wolters Kluwer
- Language
- English
- Date published
- 05/04/2023
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Orthopedics and Rehabilitation; Industrial and Systems Engineering
- Record Identifier
- 9984406146402771
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