Potassium currents in Drosophila: different components affected by mutations of two genes

Chun-Fang Wu; Barry Ganetzky; Frank N Haugland; An-Xi Liu

doi:10.1126/science.6302847

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Potassium currents in Drosophila: different components affected by mutations of two genes

Journal article

Peer reviewed

Potassium currents in Drosophila: different components affected by mutations of two genes

Chun-Fang Wu, Barry Ganetzky, Frank N Haugland and An-Xi Liu

Science (American Association for the Advancement of Science), Vol.220(4601), pp.1076-1078

06/03/1983

DOI: 10.1126/science.6302847

PMID: 6302847

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Abstract

Electrophysiological analysis of the Drosophila behavioral mutants Eag and Sh and the double mutant Eag Sh indicates that the products of both genes take part in the control of potassium currents in the membranes of both nerve and muscle. In voltage-clamped larval muscle fibers, Sh affects the transient A current, whereas Eag reduces the delayed rectification and, to a lesser extent, the A current.

Electrophysiology

Genes

Mutation

Action Potentials

Potassium - metabolism

Animals

Ion Channels - metabolism

Larva

Membrane Potentials

Neuromuscular Junction - metabolism

Muscles - metabolism

Drosophila - genetics

Details

Title: Subtitle: Potassium currents in Drosophila: different components affected by mutations of two genes
Creators: Chun-Fang Wu
Barry Ganetzky
Frank N Haugland
An-Xi Liu
Resource Type: Journal article
Publication Details: Science (American Association for the Advancement of Science), Vol.220(4601), pp.1076-1078
Publisher: United States
DOI: 10.1126/science.6302847
PMID: 6302847
ISSN: 0036-8075
eISSN: 1095-9203
Grant note: NS15797 / NINDS NIH HHS NS00675 / NINDS NIH HHS NS18500 / NINDS NIH HHS
Language: English
Date published: 06/03/1983
Academic Unit: Iowa Neuroscience Institute; Biology; Internal Medicine
Record Identifier: 9984070972702771

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