Journal article
Potential Role of Granulocyte–Monocyte Colony-Stimulating Factor in the Progression of Intracranial Aneurysms
DNA and cell biology, Vol.34(1), pp.78-81
01/01/2015
DOI: 10.1089/dna.2014.2618
PMCID: PMC4281873
PMID: 25389911
Abstract
Macrophages play a central role in the inflammatory response leading to aneurysm formation, progression, and rupture. The purpose of this study was to determine whether granulocyte–monocyte colony-stimulating factor (GM-CSF) plays a role in the progression of human intracranial aneurysms. Specifically, we investigated whether there was a correlation between the aneurysm size and the concentration of GM-CSF in the lumen of intracranial aneurysms. The concentrations of GM-CSF in blood samples drawn from the lumen of 15 human unruptured saccular intracranial aneurysms of 14 consecutive patients were compared. The aneurysm size was 10.3±9 mm on average. The mean plasma concentration of GM-CSF was 27.9±3.1 pg/mL in the lumen of intracranial aneurysms. The mean plasma concentration of GM-CSF was significantly higher in aneurysms larger than 7 mm (30.1±2.8 pg/mL) compared with aneurysms smaller than 7 mm (26.4±2.4 pg/mL;
p
=0.02). There was a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF (Spearman's rho=0.55;
p
=0.04). There is a significant positive correlation between the aneurysm size and the plasma concentration of GM-CSF in aneurysm lumens. This suggests that GM-CSF, through its stimulatory function on macrophages, may promote aneurysm progression and may be a possible therapeutic target.
Details
- Title: Subtitle
- Potential Role of Granulocyte–Monocyte Colony-Stimulating Factor in the Progression of Intracranial Aneurysms
- Creators
- Nohra Chalouhi - Department of Neurosurgery, Jefferson Hospital for NeuroscienceThana Theofanis - Department of Neurosurgery, Jefferson Hospital for NeuroscienceRobert M Starke - Department of NeurosurgeryMario Zanaty - Department of Neurosurgery, Jefferson Hospital for NeurosciencePascal Jabbour - Department of Neurosurgery, Jefferson Hospital for NeuroscienceSarah A Dooley - Department of Neurosurgery, Carver College of MedicineDavid Hasan - Department of Neurosurgery, Carver College of Medicine
- Resource Type
- Journal article
- Publication Details
- DNA and cell biology, Vol.34(1), pp.78-81
- DOI
- 10.1089/dna.2014.2618
- PMID
- 25389911
- PMCID
- PMC4281873
- NLM abbreviation
- DNA Cell Biol
- ISSN
- 1044-5498
- eISSN
- 1557-7430
- Publisher
- Mary Ann Liebert, Inc
- Language
- English
- Date published
- 01/01/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Iowa Neuroscience Institute; Neurosurgery; Otolaryngology
- Record Identifier
- 9984040352302771
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