Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity

Wen Wen; Hui Li; Jia Luo

doi:10.1007/s12035-022-02786-7

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Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity

Journal article

Peer reviewed

Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity

Wen Wen, Hui Li and Jia Luo

Molecular neurobiology, Vol.59, pp.2992-3015

03/07/2022

DOI: 10.1007/s12035-022-02786-7

PMID: 35254650

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https://pmc.ncbi.nlm.nih.gov/articles/PMC10928853/pdf/nihms-1970747.pdfView

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Abstract

Alcohol exposure during pregnancy is harmful to the fetus and causes a wide range of long-lasting physiological and neurocognitive impairments, collectively referred to as fetal alcohol spectrum disorders (FASD). The neurobehavioral deficits observed in FASD result from structural and functional damages in the brain, with neurodegeneration being the most destructive consequence. Currently, there are no therapies for FASD. It is exigent to delineate the underlying mechanisms of alcohol neurotoxicity and develop an effective strategy of treatment. ER stress, caused by the accumulation of unfolded/misfolded proteins in the ER, is the hallmark of many neurodegenerative diseases, including alcohol-induced neurodegeneration. Mesencephalic astrocyte-derived neurotrophic factor (MANF) is a newly discovered endoplasmic reticulum (ER) stress responsive neurotrophic factor that regulates diverse neuronal functions. This review summarizes the recent findings revealing the effects of MANF on the CNS and its protective role against neurodegeneration. Particularly, we focus the role of MANF on alcohol-induced ER stress and neurodegeneration and discuss the therapeutic potential of MANF in treating alcohol neurotoxicity such as FASD.

Neuroprotection

Neurotrophic factor

Alcohol abuse

Neurodegeneration

Neuronal development

Details

Title: Subtitle: Potential Role of MANF, an ER Stress Responsive Neurotrophic Factor, in Protecting Against Alcohol Neurotoxicity
Creators: Wen Wen - University of Iowa
Hui Li - University of Iowa
Jia Luo - Iowa City VA Health Care System
Resource Type: Journal article
Publication Details: Molecular neurobiology, Vol.59, pp.2992-3015
DOI: 10.1007/s12035-022-02786-7
PMID: 35254650
NLM abbreviation: Mol Neurobiol
ISSN: 0893-7648
eISSN: 1559-1182
Grant note: AA015407 / NIAAA NIH HHS BX001721 / U.S. Department of Veterans Affairs AA017226 / NIAAA NIH HHS
Language: English
Date published: 03/07/2022
Academic Unit: Pathology
Record Identifier: 9984226809702771

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