Journal article
Potential Role of Soluble Metal Impurities in the Acute Lung Inflammogenicity of Multi-Walled Carbon Nanotubes
Nanomaterials (Basel, Switzerland), Vol.10(2), p.379
02/21/2020
DOI: 10.3390/nano10020379
PMCID: PMC7075329
PMID: 32098206
Abstract
Multi-walled carbon nanotubes (MWCNTs) have variable metal impurities, but little is known about the impact of soluble metal impurities on the toxicity of MWCNTs. Here, we evaluated the role of soluble metal impurities to the acute inflammogenic potential of MWCNTs, using five types of high purity MWCNTs (>95%). MWCNTs and their soluble fractions collected at 24 h after incubation in phosphate-buffered saline showed diverse metal impurities with variable concentrations. The fiber-free soluble fractions produced variable levels of reactive oxygen species (ROS), and the iron level was the key determinant for ROS production. The acute inflammation at 24 h after intratracheal instillation of MWCNTs to rats at 0.19, 0.63, and 1.91 mg MWCNT/kg body weight (bw) or fiber-free supernatants from MWCNT suspensions at 1.91 and 7.64 mg MWCNT/kg bw showed that the number of granulocytes, a marker for acute inflammation, was significantly increased with a good dose-dependency. The correlation study showed that neither the levels of iron nor the ROS generation potential of the soluble fractions showed any correlations with the inflammogenic potential. However, the total concentration of transition metals in the soluble fractions showed a good correlation with the acute lung inflammogenic potential. These results implied that metal impurities, especially transitional metals, can contribute to the acute inflammogenic potential of MWCNTs, although the major parameter for the toxicity of MWCNTs is size and shape.
Details
- Title: Subtitle
- Potential Role of Soluble Metal Impurities in the Acute Lung Inflammogenicity of Multi-Walled Carbon Nanotubes
- Creators
- Dong-Keun Lee - Lab of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, KoreaSoyeon Jeon - Lab of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, KoreaJiyoung Jeong - Lab of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, KoreaIl Je Yu - HCTm Co., LTD., 74, Seoicheon-ro 578 beon-gil Majang-myeon, Icheon-si, Gyeonggi-do 17383, KoreaKyung Seuk Song - Korea Conformity Laboratories, 8, Gaetbeol-ro 145 beon-gil, Yeonsu-gu, Incheon 21999, KoreaAeyeon Kang - Department of Chemistry, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, KoreaWan Soo Yun - Department of Chemistry, Sungkyunkwan University, 2066, Seobu-ro, Jangan-gu, Suwon-si, Gyeonggi-do 16419, KoreaJong Sung Kim - Department of Community Health and Epidemiology, Dalhousie University, Halifax, Nova Scotia B3H4R2, CanadaWan-Seob Cho - Lab of Toxicology, Department of Medicinal Biotechnology, College of Health Sciences, Dong-A University, Busan 49315, Korea
- Resource Type
- Journal article
- Publication Details
- Nanomaterials (Basel, Switzerland), Vol.10(2), p.379
- DOI
- 10.3390/nano10020379
- PMID
- 32098206
- PMCID
- PMC7075329
- NLM abbreviation
- Nanomaterials (Basel)
- ISSN
- 2079-4991
- eISSN
- 2079-4991
- Grant note
- BB21+ project / Busan Metropolitan City NRF-2019R1A2C1084489 / National Research Foundation of Korea NRF-2018K1A3A1A74065871 / National Research Foundation of Korea
- Language
- English
- Date published
- 02/21/2020
- Academic Unit
- Occupational and Environmental Health
- Record Identifier
- 9984214782702771
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