Journal article
Potential evidence of peritoneal recurrence in Stage-II colon cancer from the control arm of CALGB9581
The American journal of surgery, Vol.224(1), pp.459-464
07/2022
DOI: 10.1016/j.amjsurg.2022.01.017
PMID: 35090686
Abstract
Relapse of early-stage colon cancer (CC) after curative-intent resection occurs. We hypothesized that known risk factors for peritoneal metastases (PM) can define a high-risk state (HRS) that predicts recurrence and mortality.
CALGB9581 trial patients receiving no adjuvant treatment after stage-II CC resection were included. Positive radial margins, T4 invasion, obstruction/perforation or lymphovascular invasion defined the HRS. Cox proportional hazard models determined association with overall (OS) and disease-free survival (DFS).
Median follow-up in 873 included patients was 8.1 years. Five-year OS was 85.8%. HRS+ patients had lower 5-year DFS (68.7 vs. 82.4%, P = 0.003) and OS (75.5 vs. 87.8%, P = 0.001). HRS+ was independently predictive of worse DFS and OS (HR 1.52 and 1.64, P < 0.01). Among recurrences, HRS+ patients showed shorter median OS (3.3 vs. 5.3 years, P = 0.01).
HRS criteria identify a cohort of CC patients at high-risk of recurrence and death. Studies of novel surveillance techniques in such patients are warranted.
•Early-stage patients in CALGB9581 control arm underwent curative-intent resection.•Relapse of early-stage colon cancer may present as peritoneal metastases.•High-risk factors for peritoneal metastases are associated with poorer survival.•Studies of novel surveillance protocols are warranted for high-risk patients.
Details
- Title: Subtitle
- Potential evidence of peritoneal recurrence in Stage-II colon cancer from the control arm of CALGB9581
- Creators
- Fadi S. Dahdaleh - University of ChicagoScott K. Sherman - University of ChicagoHunter D.D. Witmer - University of ChicagoAnkit Dhiman - University of ChicagoRahul Rajeev - The University of Texas Rio Grande ValleyElizabeth C. Poli - University of ChicagoFabian M. Johnston - Johns Hopkins UniversityKiran K. Turaga - University of Chicago
- Resource Type
- Journal article
- Publication Details
- The American journal of surgery, Vol.224(1), pp.459-464
- Publisher
- Elsevier Inc
- DOI
- 10.1016/j.amjsurg.2022.01.017
- PMID
- 35090686
- ISSN
- 0002-9610
- eISSN
- 1879-1883
- Language
- English
- Date published
- 07/2022
- Academic Unit
- Surgery
- Record Identifier
- 9984322931802771
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