Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health

Colleen L McHenry; Jason Wu; Richard K Shields

doi:10.1186/1756-0500-7-334

Back

Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health

Journal article

Open access

Peer reviewed

Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health

Colleen L McHenry, Jason Wu and Richard K Shields

BMC research notes, Vol.7(1), pp.334-334

06/03/2014

DOI: 10.1186/1756-0500-7-334

PMCID: PMC4055276

PMID: 24894666

Files and links (1)

url

https://doi.org/10.1186/1756-0500-7-334View

Published (Version of record) Open Access

Abstract

Mechanical loads induced through muscle contraction, vibration, or compressive forces are thought to modulate tissue plasticity. With the emergence of regenerative medicine, there is a need to understand the optimal mechanical environment (vibration, load, or muscle force) that promotes cellular health. To our knowledge no mechanical system has been proposed to deliver these isolated mechanical stimuli in human tissue. We present the design, performance, and utilization of a new technology that may be used to study localized mechanical stimuli on human tissues. A servo-controlled vibration and limb loading system were developed and integrated into a single instrument to deliver vibration, compression, or muscle contractile loads to a single limb (tibia) in humans. The accuracy, repeatability, transmissibility, and safety of the mechanical delivery system were evaluated on eight individuals with spinal cord injury (SCI). The limb loading system was linear, repeatable, and accurate to less than 5, 1, and 1 percent of full scale, respectively, and transmissibility was excellent. The between session tests on individuals with spinal cord injury (SCI) showed high intra-class correlations (>0.9). All tests supported that therapeutic loads can be delivered to a lower limb (tibia) in a safe, accurate, and measureable manner. Future collaborations between engineers and cellular physiologists will be important as research programs strive to determine the optimal mechanical environment for developing cells and tissues in humans.

Stress, Mechanical

Regeneration

Vibration

Humans

Details

Title: Subtitle: Potential regenerative rehabilitation technology: implications of mechanical stimuli to tissue health
Creators: Colleen L McHenry
Jason Wu
Richard K Shields - Department of Physical Therapy & Rehabilitation Science, Carver College of Medicine, University of Iowa, 1-252 Medical Education Building, Iowa City, IA 52242-1190, USA. richard-shields@uiowa.edu
Resource Type: Journal article
Publication Details: BMC research notes, Vol.7(1), pp.334-334
DOI: 10.1186/1756-0500-7-334
PMID: 24894666
PMCID: PMC4055276
NLM abbreviation: BMC Res Notes
ISSN: 1756-0500
eISSN: 1756-0500
Publisher: England
Grant note: R01 HD062507 / NICHD NIH HHS R01-HD-062507 / NICHD NIH HHS
Language: English
Date published: 06/03/2014
Academic Unit: Orthopedics and Rehabilitation; Physical Therapy and Rehabilitation Science
Record Identifier: 9984046933602771

Metrics

16 Record Views