Potential reliability and validity of a modified version of the Unified Parkinson's Disease Rating Scale that could be administered remotely

Amir Abdolahi; Nicholas Scoglio; Annie Killoran; E. Ray Dorsey; Kevin M Biglan

doi:10.1016/j.parkreldis.2012.10.008

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Potential reliability and validity of a modified version of the Unified Parkinson's Disease Rating Scale that could be administered remotely

Journal article

Peer reviewed

Potential reliability and validity of a modified version of the Unified Parkinson's Disease Rating Scale that could be administered remotely

Amir Abdolahi, Nicholas Scoglio, Annie Killoran, E. Ray Dorsey and Kevin M Biglan

Parkinsonism & related disorders, Vol.19(2), pp.218-221

02/2013

DOI: 10.1016/j.parkreldis.2012.10.008

PMCID: PMC3666325

PMID: 23102808

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https://www.ncbi.nlm.nih.gov/pmc/articles/3666325View

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Abstract

By permitting remote assessments of patients and research participants, telemedicine has the potential to reshape clinical care and clinical trials for Parkinson disease. While the majority of the motor Unified Parkinson's Disease Rating Scale (UPDRS) items can be conducted visually, rigidity and retropulsion pull testing require hands-on assessment by the rater and are less feasible to perform remotely in patients' homes. In a secondary data analysis of the Comparison of the Agonist pramipexole vs. Levodopa on Motor complications in Parkinson's Disease (CALM-PD) study, a randomized clinical trial, we assessed the cross-sectional (baseline and 2 years) and longitudinal (change from baseline to 2 years) reliability of a modified motor UPDRS (removing rigidity and retropulsion items) compared to the standard motor UPDRS (all items) using intraclass correlation coefficients (ICC), stratified by treatment group. Internal consistency of the modified UPDRS (mUPDRS) was measured using Cronbach's alpha, and concurrent validity was assessed using Pearson's correlation coefficient (r) between the standard motor UPDRS and mUPDRS. The mUPDRS versus standard motor UPDRS is cross-sectionally (ICC ≥ 0.92) and longitudinally (ICC ≥ 0.92) reliable for both treatment groups. High internal consistencies were also observed (α ≥ 0.96). The mUPDRS had high concurrent validity with the standard UPDRS at both time points and longitudinally (r ≥ 0.93, p < 0.0001). A modified version of the motor UPDRS without rigidity and retropulsion pull testing is reliable and valid and may lay the foundation for its use in remote assessments of patients and research participants.

Validity

Parkinson's disease

Telemedicine

Motor

UPDRS

Reliability

CALM-PD

Details

Title: Subtitle: Potential reliability and validity of a modified version of the Unified Parkinson's Disease Rating Scale that could be administered remotely
Creators: Amir Abdolahi - Department of Community and Preventive Medicine, University of Rochester, School of Medicine and Dentistry, 265 Crittenden Blvd., CU 420644, Rochester, NY 14642, USA
Nicholas Scoglio - Department of Neurology, University of Rochester, Rochester, NY, USA
Annie Killoran - Department of Neurology, University of Rochester, Rochester, NY, USA
E. Ray Dorsey - Department of Neurology, Johns Hopkins University, Baltimore, MD, USA
Kevin M Biglan - Department of Neurology, University of Rochester, Rochester, NY, USA
Resource Type: Journal article
Publication Details: Parkinsonism & related disorders, Vol.19(2), pp.218-221
DOI: 10.1016/j.parkreldis.2012.10.008
PMID: 23102808
PMCID: PMC3666325
NLM abbreviation: Parkinsonism Relat Disord
ISSN: 1353-8020
eISSN: 1873-5126
Publisher: Elsevier Ltd
Language: English
Date published: 02/2013
Academic Unit: Neurology; Psychiatry
Record Identifier: 9984020899002771

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