Journal article
Potential role of the glycolytic oscillator in acute hypoxia in tumors
Physics in medicine & biology, Vol.60(24), pp.9215-9225
11/17/2015
DOI: 10.1088/0031-9155/60/24/9215
PMCID: PMC4833657
PMID: 26576743
Abstract
Tumor acute hypoxia has a dynamic component that is also, at least partially, coherent. Using blood oxygen level dependent magnetic resonance imaging, we observed coherent oscillations in hemoglobin saturation dynamics in cell line xenograft models of head and neck squamous cell carcinoma. We posit a well-established biochemical nonlinear oscillatory mechanism called the glycolytic oscillator as a potential cause of the coherent oscillations in tumors. These data suggest that metabolic changes within individual tumor cells may affect the local tumor microenvironment including oxygen availability and therefore radiosensitivity. These individual cells can synchronize the oscillations in patches of similar intermediate glucose levels. These alterations have potentially important implications for radiation therapy and are a potential target for optimizing the cancer response to radiation.
Details
- Title: Subtitle
- Potential role of the glycolytic oscillator in acute hypoxia in tumors
- Creators
- Leonard Che Fru - University of Wisconsin–MadisonErin B Adamson - University of Wisconsin–MadisonDavid D Campos - University of Wisconsin–MadisonSean B Fain - University of Wisconsin–MadisonSteven L Jacques - Oregon Health & Science UniversityAlbert J van der Kogel - University of Wisconsin–MadisonKwang P Nickel - University of Wisconsin–MadisonChihwa Song - University of Wisconsin–MadisonRandall J Kimple - University of Wisconsin–MadisonMichael W Kissick - University of Wisconsin–Madison
- Resource Type
- Journal article
- Publication Details
- Physics in medicine & biology, Vol.60(24), pp.9215-9225
- DOI
- 10.1088/0031-9155/60/24/9215
- PMID
- 26576743
- PMCID
- PMC4833657
- NLM abbreviation
- Phys Med Biol
- ISSN
- 0031-9155
- eISSN
- 1361-6560
- Publisher
- IOP Publishing
- Number of pages
- 11
- Grant note
- NIH/NCI P30 CA014520 / University of Wisconsin Carbone Cancer Center (http://dx.doi.org/10.13039/100007923) T32 CA009206; R00 CA160639 / The National Cancer Institute of the National Institutes of Health
- Alternative title
- Potential role of the glycolytic oscillator in acute hypoxia in tumors
- Language
- English
- Date published
- 11/17/2015
- Academic Unit
- Roy J. Carver Department of Biomedical Engineering; Radiology; Electrical and Computer Engineering; Health, Sport, and Human Physiology
- Record Identifier
- 9984274954502771
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