Journal article
Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons
Science (New York, N.Y.), Vol.266(5192), pp.1881-1885
12/16/1994
DOI: 10.1126/science.7997883
PMID: 7997883
Abstract
Calcium-calmodulin-dependent protein kinase II (CaMKII) is a necessary component of the cellular machinery underlying learning and memory. Here, a constitutively active form of this enzyme, CaMKII(1-290), was introduced into neurons of hippocampal slices with a recombinant vaccinia virus to test the hypothesis that increased postsynaptic activity of this enzyme is sufficient to produce long-term synaptic potentiation (LTP), a prominent cellular model of learning and memory. Postsynaptic expression of CaMKII(1-290) increased CaMKII activity, enhanced synaptic transmission, and prevented more potentiation by an LTP-inducing protocol. These results, together with previous studies, suggest that postsynaptic CaMKII activity is necessary and sufficient to generate LTP.
Details
- Title: Subtitle
- Potentiated transmission and prevention of further LTP by increased CaMKII activity in postsynaptic hippocampal slice neurons
- Creators
- D L Pettit - Neuroscience Program, University of Iowa, Iowa City 52242S PerlmanR Malinow
- Resource Type
- Journal article
- Publication Details
- Science (New York, N.Y.), Vol.266(5192), pp.1881-1885
- DOI
- 10.1126/science.7997883
- PMID
- 7997883
- NLM abbreviation
- Science
- ISSN
- 0036-8075
- eISSN
- 1095-9203
- Publisher
- United States
- Language
- English
- Date published
- 12/16/1994
- Academic Unit
- Microbiology and Immunology; Stead Family Department of Pediatrics; Iowa Neuroscience Institute; Infectious Disease (Pediatrics)
- Record Identifier
- 9983777347502771
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