Journal article
Potentiation of vasoconstrictor responses to serotonin in the limb of atherosclerotic monkeys
Journal of hypertension. Supplement, Vol.4(1), pp.S17-S21
04/1986
PMID: 2939210
Abstract
Vasoconstrictor responses to serotonin and norepinephrine were examined in: normal cynomolgus monkeys, atherosclerotic monkeys that were fed atherogenic diet for 3-5 years and hypercholesterolaemic but non-atherosclerotic monkeys that were fed atherogenic diet for 4-5 months. Serotonin decreased total hindlimb resistance in normal and hypercholesterolaemic monkeys, but increased total resistance in atherosclerotic monkeys. There was a greater than 10-fold increase in constrictor responses of large arteries to serotonin in atherosclerotic compared with normal and hypercholesterolaemic monkeys. In contrast, responses to norepinephrine were not increased in atherosclerotic monkeys. Thus, atherosclerosis greatly potentiates constrictor responses to serotonin in large arteries of the limb. This potentiation appears to be somewhat selective for serotonin, as it is not observed with norepinephrine.
Details
- Title: Subtitle
- Potentiation of vasoconstrictor responses to serotonin in the limb of atherosclerotic monkeys
- Creators
- D D HeistadM L ArmstrongM L MarcusD J PiegorsA L Mark
- Resource Type
- Journal article
- Publication Details
- Journal of hypertension. Supplement, Vol.4(1), pp.S17-S21
- Publisher
- England
- PMID
- 2939210
- ISSN
- 0952-1178
- Grant note
- HL 14230 / NHLBI NIH HHS HL 14388 / NHLBI NIH HHS HL 16066 / NHLBI NIH HHS
- Language
- English
- Date published
- 04/1986
- Academic Unit
- Cardiovascular Medicine; Neuroscience and Pharmacology; Internal Medicine
- Record Identifier
- 9984040532002771
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