Journal article
Powerful immunosuppression mediated by interleukin 2-activated, nonantigen-specific, or H-2-restricted THY-1 + CD8 + cells
Cellular immunology, Vol.124(1), pp.50-63
1989
DOI: 10.1016/0008-8749(89)90111-1
PMID: 2572330
Abstract
Normal spleen cells cultured in high or low concentrations of interleukin (IL) 2 for 3 days contain Thy-1
+ CD4
− CD8
+ cells that powerfully suppress primary but not ongoing or active lymphocyte responses. The precursors of these cells are Thy-1
+AGM-1
− and are absent or present in greatly diminished numbers in athymic and scid mice. Suppression is neither antigen nor H-2 restricted and apparently results from reversible inactivation of resting lymphocytes. Comparable Thy-1
+ CD8
+ suppressor cells were also recovered from normal spleen cells cultured for 3 days with anti-CD3 antibody without added IL-2, indicating that these cells can be activated during the course of immune responses. Such cells may prevent local recruitment/activation of lymphocytes specific for new epitopes that may be expressed sequentially by proliferating tumor cells or infectious organisms.
Details
- Title: Subtitle
- Powerful immunosuppression mediated by interleukin 2-activated, nonantigen-specific, or H-2-restricted THY-1 + CD8 + cells
- Creators
- Guillermo Torre-AmioneRebecca TuetkenDonald A Rowley
- Resource Type
- Journal article
- Publication Details
- Cellular immunology, Vol.124(1), pp.50-63
- Publisher
- Elsevier Inc
- DOI
- 10.1016/0008-8749(89)90111-1
- PMID
- 2572330
- ISSN
- 0008-8749
- eISSN
- 1090-2163
- Language
- English
- Date published
- 1989
- Academic Unit
- Immunology; Internal Medicine
- Record Identifier
- 9984094512102771
Metrics
20 Record Views