Practical Considerations for Implementation of 177Lu-DOTATATE Neuroendocrine Tumor Treatment Programs

Diane K. Soulek; Molly E. Martin; Nic J. Mastascusa; Stephen A. Graves

doi:10.2967/jnmt.122.263813

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Practical Considerations for Implementation of 177Lu-DOTATATE Neuroendocrine Tumor Treatment Programs

Journal article

Open access

Peer reviewed

Practical Considerations for Implementation of 177Lu-DOTATATE Neuroendocrine Tumor Treatment Programs

Diane K. Soulek, Molly E. Martin, Nic J. Mastascusa and Stephen A. Graves

Journal of nuclear medicine technology, Vol.50(3), pp.195-202

09/01/2022

DOI: 10.2967/jnmt.122.263813

PMID: 35701215

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https://doi.org/10.2967/jnmt.122.263813View

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Abstract

The 2018 Food and Drug Administration approval of( 177)Lu-DOTA-TATE for the treatment of somatostatin receptor-positive neuroen-docrine tumors (NETs) represents a paradigm-shifting approach to cancer treatments around the globe. Gastroenteropancreatic NETs overexpress the somatostatin subtype receptor 2, which is now exploited for receptor-based imaging and therapy, thus generating significant progress in the diagnosis and treatment of this orphan disease. The recent Food and Drug Administration approval of receptor-based PET radiopharmaceuticals and a new peptide receptor radiopharmaceutical therapy,Lu- 177-DOTATATE, has dra-matically impacted NET patient management. The focus of this paper is to review clinical considerations associated with imple-menting a Lu-177-DOTATATE program. We review receptor-based NET radiopharmaceuticals;Lu- 177-DOTATATE patient selection cri-teria; administration methods; clinical, regulatory, and radiation safety considerations; technical factors; tissue dosimetry; and reimbursement guidelines.

Life Sciences & Biomedicine

Radiology, Nuclear Medicine & Medical Imaging

Science & Technology

Details

Title: Subtitle: Practical Considerations for Implementation of 177Lu-DOTATATE Neuroendocrine Tumor Treatment Programs
Creators: Diane K. Soulek - University of Iowa Hospitals and Clinics
Molly E. Martin - University of Iowa
Nic J. Mastascusa - University of Iowa
Stephen A. Graves - University of Iowa
Resource Type: Journal article
Publication Details: Journal of nuclear medicine technology, Vol.50(3), pp.195-202
DOI: 10.2967/jnmt.122.263813
PMID: 35701215
NLM abbreviation: J Nucl Med Technol
ISSN: 0091-4916
eISSN: 1535-5675
Publisher: Soc Nuclear Medicine Inc
Number of pages: 8
Language: English
Date published: 09/01/2022
Academic Unit: Roy J. Carver Department of Biomedical Engineering; Radiology; Radiation Oncology; Pharmacy Practice and Science
Record Identifier: 9984383919602771

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