Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment

Kevin Duff; Constantine G Lyketsos; Leigh J Beglinger; Gordon Chelune; David J Moser; Stephan Arndt; Susan K Schultz; Jane S Paulsen; Ronald C Petersen; Robert J McCaffrey

doi:10.1097/JGP.0b013e318209dd3a

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Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment

Journal article

Peer reviewed

Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment

Kevin Duff, Constantine G Lyketsos, Leigh J Beglinger, Gordon Chelune, David J Moser, Stephan Arndt, Susan K Schultz, Jane S Paulsen, Ronald C Petersen and Robert J McCaffrey

The American journal of geriatric psychiatry, Vol.19(11), pp.932-939

11/2011

DOI: 10.1097/JGP.0b013e318209dd3a

PMCID: PMC3202689

PMID: 22024617

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https://www.ncbi.nlm.nih.gov/pmc/articles/3202689View

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Abstract

Practice effects on cognitive tests have been shown to further characterize patients with amnestic mild cognitive impairment (aMCI) and may provide predictive information about cognitive change across time. We tested the hypothesis that a loss of practice effects would portend a worse prognosis in aMCI. Longitudinal, observational design following participants across 1 year. Community-based cohort. Three groups of older adults: 1) cognitively intact (n = 57), 2) aMCI with large practice effects across 1 week (MCI + PE, n = 25), and 3) aMCI with minimal practice effects across 1 week (MCI − PE, n = 26). Neuropsychological tests. After controlling for age and baseline cognitive differences, the MCI − PE group performed significantly worse than the other groups after 1 year on measures of immediate memory, delayed memory, language, and overall cognition. Although these results need to be replicated in larger samples, the loss of short-term practice effects portends a worse prognosis in patients with aMCI.

practice effects

mild cognitive impairment

Dementia

Details

Title: Subtitle: Practice Effects Predict Cognitive Outcome in Amnestic Mild Cognitive Impairment
Creators: Kevin Duff - Department of Neurology, University of Utah, Salt Lake City
Constantine G Lyketsos - Department of Psychiatry and Behavioral Sciences, Johns Hopkins University, Baltimore, MD
Leigh J Beglinger - Department of Psychiatry, University of Iowa, Iowa City
Gordon Chelune - Department of Neurology, University of Utah, Salt Lake City
David J Moser - Department of Psychiatry, University of Iowa, Iowa City
Stephan Arndt - College of Public Health, Department of Biostatistics, Iowa City
Susan K Schultz - Department of Psychiatry, University of Iowa, Iowa City
Jane S Paulsen - Department of Psychiatry, University of Iowa, Iowa City
Ronald C Petersen - Alzheimer's Disease Research Center, Mayo Clinic College of Medicine, Rochester, MN
Robert J McCaffrey - Department of Psychology, University at Albany, State University of New York
Resource Type: Journal article
Publication Details: The American journal of geriatric psychiatry, Vol.19(11), pp.932-939
DOI: 10.1097/JGP.0b013e318209dd3a
PMID: 22024617
PMCID: PMC3202689
NLM abbreviation: Am J Geriatr Psychiatry
ISSN: 1064-7481
eISSN: 1545-7214
Publisher: Elsevier Inc
Grant note: K23 AG028417–01A2; P50AG005 / grants from the National Institutes on Aging:
Language: English
Date published: 11/2011
Academic Unit: Psychiatry; Psychological and Brain Sciences; Biostatistics; Nursing; Injury Prevention Research Center; Medicine Administration; Internal Medicine
Record Identifier: 9984003464202771

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