Journal article
Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder
Journal of psychiatric research, Vol.82, pp.126-135
11/2016
DOI: 10.1016/j.jpsychires.2016.07.017
PMCID: PMC5026935
PMID: 27494079
Abstract
Pre- and perinatal complications have been implicated in the onset and clinical expression of Tourette syndrome albeit with considerable inconsistencies across studies. Also, little is known about their role in co-occurring obsessive-compulsive disorder (OCD) and attention–deficit/hyperactivity disorder (ADHD) in individuals with a tic disorder. Therefore, we aimed to investigate the role of pre- and perinatal complications in relation to the presence and symptom severity of chronic tic disorder and co-occurring OCD and ADHD using data of 1113 participants from the Tourette International Collaborative Genetics study. This study included 586 participants with a chronic tic disorder and 527 unaffected family controls. We controlled for age and sex differences by creating propensity score matched subsamples for both case-control and within-case analyses. We found that premature birth (OR = 1.72) and morning sickness requiring medical attention (OR = 2.57) were associated with the presence of a chronic tic disorder. Also, the total number of pre- and perinatal complications was higher in those with a tic disorder (OR = 1.07). Furthermore, neonatal complications were related to the presence (OR = 1.46) and severity (b = 2.27) of co-occurring OCD and also to ADHD severity (b = 1.09). Delivery complications were only related to co-occurring OCD (OR = 1.49). We conclude that early exposure to adverse situations during pregnancy is related to the presence of chronic tic disorders. Exposure at a later stage, at birth or during the first weeks of life, appears to be associated with co-occurring OCD and ADHD.
Details
- Title: Subtitle
- Pre- and perinatal complications in relation to Tourette syndrome and co-occurring obsessive-compulsive disorder and attention-deficit/hyperactivity disorder
- Creators
- Mohamed Abdulkadir - Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USAJay A Tischfield - Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USARobert A King - Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USAThomas V Fernandez - Yale Child Study Center and Department of Psychiatry, Yale University School of Medicine, New Haven, CT, USALawrence W Brown - Children's Hospital of Philadelphia, Philadelphia, PA, USAKeun-Ah Cheon - Yonsei University College of Medicine, Severance Hospital, Seoul, South KoreaBarbara J Coffey - Icahn School of Medicine at Mount Sinai, New York, NY, USASebastian F.T.M de Bruijn - Haga Teaching Hospital, Department of Neurology, The Hague, The NetherlandsLonneke Elzerman - Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The NetherlandsBlanca Garcia-Delgar - Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari, Barcelona, SpainDonald L Gilbert - Cincinnati Children's Hospital Medical Center, Cincinnati, OH, USADorothy E Grice - Icahn School of Medicine at Mount Sinai, New York, NY, USAJulie Hagstrøm - Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, DenmarkTammy Hedderly - Evelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UKIsobel Heyman - Great Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UKHyun Ju Hong - Hallym University Sacred Heart Hospital, Anyang, South KoreaChaim Huyser - De Bascule, AMC Department of Child and Adolescent Psychiatry, Amsterdam, The NetherlandsLaura Ibanez-Gomez - Icahn School of Medicine at Mount Sinai, New York, NY, USAYoung Key Kim - Yonsei Bom Clinic, South KoreaYoung-Shin Kim - Department of Psychiatry, University of California, San Francisco, USAYun-Joo Koh - Korea Institute for Children's Social Development, Seoul, South KoreaSodahm Kook - MyongJi Hospital, Koyang, South KoreaSamuel Kuperman - University of Iowa Carver College of Medicine, Iowa City, IA, USAAndreas Lamerz - Triversum, Center for Child and Adolescent Psychiatry, Alkmaar, The NetherlandsBennett Leventhal - Department of Psychiatry, University of California, San Francisco, USAAndrea G Ludolph - University of Ulm, Department of Child and Adolescent Psychiatry and Psychotherapy, Ulm, GermanyMarcos Madruga-Garrido - Sección de Neuropediatría, Instituto de Biomedicina de Sevilla, Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, SpainAthanasios Maras - Yulius Academy and Division Child and Adolescent Psychiatry, Yulius Mental Health Organization, Barendrecht, The NetherlandsMarieke D Messchendorp - University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The NetherlandsPablo Mir - Unidad de Trastornos del Movimiento, Instituto de Biomedicina de Sevilla (IBiS), Hospital Universitario Virgen del Rocío/CSIC/Universidad de Sevilla, Seville, SpainAstrid Morer - Department of Child and Adolescent Psychiatry and Psychology, Institute of Neurosciences, Hospital Clinic Universitari Barcelona, SpainAlexander Münchau - Institute of Neurogenetics, University of Lübeck, Lübeck, GermanyTara L Murphy - Great Ormond Street Hospital for Children, and UCL Institute of Child Health, London, UKThaïra J.C Openneer - University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The NetherlandsKerstin J Plessen - Child and Adolescent Mental Health Center, Mental Health Services, Capital Region of Denmark and Faculty of Health Sciences, University of Copenhagen, DenmarkJudith J.G Rath - Haga Teaching Hospital, Department of Neurology, The Hague, The NetherlandsVeit Roessner - Department of Child and Adolescent Psychiatry, TU Dresden, GermanyOdette Fründt - University Hospital Medical Center Hamburg-Eppendorf, Hamburg, GermanyEun-Young Shin - Yonsei University College of Medicine, Severance Hospital, Seoul, South KoreaDeborah A Sival - University of Groningen, University Medical Center Groningen, Department of Pediatrics, Groningen, The NetherlandsDong-Ho Song - Yonsei University College of Medicine, Severance Hospital, Seoul, South KoreaJungeun Song - National Health Insurance Service Ilsan Hospital, Goyang-si, South KoreaAnne-Marie Stolte - Accare, Child and Adolescent Psychiatry, Groningen, The NetherlandsJennifer Tübing - Institute of Neurogenetics, University of Lübeck, Lübeck, GermanyEls van den Ban - Youth Division, Altrecht, Institute for Mental Health, Utrecht, The NetherlandsFrank Visscher - Admiraal De Ruyter Ziekenhuis, Department of Neurology, Goes, The NetherlandsSina Wanderer - Department of Child and Adolescent Psychiatry, TU Dresden, GermanyMartin Woods - Evelina London Children's Hospital GSTT, Kings Health Partners AHSC, London, UKSamuel H Zinner - University of Washington, Department of Pediatrics, Seattle, WA, USAMatthew W State - Department of Psychiatry, University of California, San Francisco, USAGary A Heiman - Rutgers, The State University of New Jersey, Department of Genetics and the Human Genetics Institute of New Jersey, Piscataway, NJ, USAPieter J Hoekstra - University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The NetherlandsAndrea Dietrich - University of Groningen, University Medical Center Groningen, Department of Child and Adolescent Psychiatry, Groningen, The Netherlands
- Resource Type
- Journal article
- Publication Details
- Journal of psychiatric research, Vol.82, pp.126-135
- DOI
- 10.1016/j.jpsychires.2016.07.017
- PMID
- 27494079
- PMCID
- PMC5026935
- NLM abbreviation
- J Psychiatr Res
- ISSN
- 0022-3956
- eISSN
- 1879-1379
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 11/2016
- Academic Unit
- Psychiatry; Stead Family Department of Pediatrics
- Record Identifier
- 9984003444202771
Metrics
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