Journal article
Pre-operative assessment and post-operative outcomes of elderly women with gynecologic cancers, primary analysis of NRG CC-002: An NRG oncology group/gynecologic oncology group study
Gynecologic Oncology, Vol.150(2), pp.300-305
08/2018
DOI: 10.1016/j.ygyno.2018.05.022
PMCID: PMC6387790
PMID: 29807694
Abstract
CC-002 is a prospective cooperative group study conducted by NRG Oncology to evaluate whether a pre-operative GA-GYN score derived from a predictive model utilizing components of an abbreviated geriatric assessment (GA) is associated with major post-operative complications in elderly women with suspected ovarian, fallopian tube, primary peritoneal or advanced stage papillary serous uterine (GYN) carcinoma undergoing primary open cytoreductive surgery. Patients 70 years or older with suspected advanced gynecologic cancers undergoing evaluation for surgery were eligible. A GA-GYN score was derived from a model utilizing the GA as a pre-operative tool. Patients were followed for six weeks post-operatively or until start of chemotherapy. Post-operative events were recorded either directly as binary occurrence (yes or no) using CTCAE version 4.0. There were 189 eligible patients, 117 patients with primary surgical intervention and 37 patients undergoing interval cytoreduction surgery. The association between higher GA-GYN score and major postoperative complications in patients undergoing primary surgery was not significant (p = 0.1341). In a subgroup analysis of patients with advanced staged malignant disease who underwent primary cytoreductive surgery, there was a trend towards an association with the GA-GYN score and post-operative complications. The pre-operative GA-GYN score derived from a predictive model utilizing components of an abbreviated geriatric assessment was not predictive of major post-operative complications in elderly patients undergoing primary open cytoreductive surgery. However, there was an association between GA-GYN score and post-operative complications in a subgroup of patients with advanced staged malignant disease. •The first prospective surgical study in elderly women with gynecologic cancers•Treatment patterns of elderly women with gynecologic malignancies•Geriatric assessment scores correlate with post-operative complications
Details
- Title: Subtitle
- Pre-operative assessment and post-operative outcomes of elderly women with gynecologic cancers, primary analysis of NRG CC-002: An NRG oncology group/gynecologic oncology group study
- Creators
- Amina Ahmed - Department of OB/GYN, Division of Gyn Oncology, Rush University Medical Center, Chicago, IL 60612, United StatesWei Deng - NRG Oncology, Clinical Trial Development Division, Biostatistics & Bioinformatics, Roswell Park Cancer Institute, Buffalo, NY 4263, United StatesWilliam Tew - Department of Internal Medicine, Memorial Sloan-Kettering Cancer Center, New York, NY, United StatesDavid Bender - Gyn/Onc Division, University of Iowa, Iowa City, IA 52242, United StatesRobert S Mannel - Department of OB/GYN, University of Oklahoma, Oklahoma City, OK 73190, United StatesRamey D Littell - Kaiser Permanente Northern California Gynecologic Cancer Program, San Francisco, CA 94115, United StatesAlbert S DeNittis - Department of Radiation Oncology, Main Line Hospital, Wynnewood, PA 19096, United StatesMitchell Edelson - Hanjani Institute for Gynecologic Oncology, Abington Hospital, Jefferson Health, Abington, PA 19001, United StatesMark Morgan - Department of OB/GYN, University of Pennsylvania Hospital System, Philadelphia, PA 19104, United StatesJay Carlson - Cancer Research for the Ozarks, Springfield, MO 65804, United StatesChristopher J Darus - Division of Gynecologic Oncology, Maine Medical Center, Scarborough, ME 04074, United StatesAimee C Fleury - Department of Gynecologic Oncology, Women's Cancer Center of Nevada, Las Vegas, NV 89169, United StatesSusan Modesitt - Department of OB/GYN, University of Virginia, Charlottesville, VA 22908, United StatesAlexander Olawaiye - Department of Obstetrics & Gynecology, University of Pittsburgh Cancer Institute, Pittsburgh, PA 15213, United StatesAnthony Evans - Marshfield Clinic, OB-GYN Dept, Marshfield, WI 54449, United StatesGini F Fleming - Section of Medical Oncology, University of Chicago, Chicago, IL 60637, United States
- Resource Type
- Journal article
- Publication Details
- Gynecologic Oncology, Vol.150(2), pp.300-305
- DOI
- 10.1016/j.ygyno.2018.05.022
- PMID
- 29807694
- PMCID
- PMC6387790
- NLM abbreviation
- Gynecol Oncol
- ISSN
- 0090-8258
- eISSN
- 1095-6859
- Publisher
- Elsevier Inc
- Grant note
- 1 U10 CA180822; U10CA180868; UG1CA189867 / National Cancer Institute (https://doi.org/10.13039/100000054)
- Language
- English
- Date published
- 08/2018
- Academic Unit
- Obstetrics and Gynecology
- Record Identifier
- 9983930282702771
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