Journal article
Pre-pregnancy dietary arsenic consumption among women in the United States
Birth defects research, Vol.112(3), pp.270-277
02/01/2020
DOI: 10.1002/bdr2.1634
PMCID: PMC7099603
PMID: 31863647
Abstract
Arsenic is associated with several adverse health outcomes, including some birth defects. Although diet is the predominant route of arsenic exposure in the United States (U.S.), limited data exist regarding pre-pregnancy dietary arsenic consumption among U.S. women.\nUsing data collected in the National Birth Defects Prevention Study (NBDPS), we estimated daily dietary arsenic consumption during the year before pregnancy for 10,886 mothers of nonmalformed control children delivered from 1997-2011. Responses to the NBDPS dietary assessment and food item estimates of total and inorganic arsenic were used to estimate consumption. Associations between total and inorganic arsenic consumption and selected maternal characteristics were estimated using multinomial logistic regression.\nEstimates of mean maternal total and inorganic dietary arsenic consumption were 14.9 and 5.2 μg/day, respectively. Several positive and inverse associations with confidence intervals that excluded the null were observed. Comparing mothers in the middle or high total arsenic consumption tertiles to those in the low tertile, we observed positive associations (odds ratios = 1.3-3.8) for maternal age (≥30 years), lower (0-8 years) or higher (>12 years) education, race/ethnicity (non-Hispanic Black, Hispanic, other), and early pregnancy drinking with no binge episodes, and inverse associations (odds ratios = 0.4-0.8) for age (<25 years), body mass index (≥30.0 kg/m\n), and early pregnancy smoking. Findings tended to be similar for inorganic arsenic consumption.\nThese contemporary estimates of pre-pregnancy dietary arsenic consumption among U.S. women show associations between both total and inorganic dietary arsenic consumption and several maternal characteristics, improving characterization of the public health impact of this exposure.
Details
- Title: Subtitle
- Pre-pregnancy dietary arsenic consumption among women in the United States
- Creators
- Jonathan Suhl - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IowaKristin M Conway - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IowaAnthony Rhoads - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, IowaPeter H Langlois - Birth Defects Epidemiology and Surveillance Branch, Texas Department of State Health Services, Austin, TexasMarcia L Feldkamp - Division of Medical Genetics, Department of Pediatrics, University of Utah School of Medicine, Salt Lake City, UtahAdrian Michalski - New York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New YorkPaul A Romitti - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa
- Resource Type
- Journal article
- Publication Details
- Birth defects research, Vol.112(3), pp.270-277
- DOI
- 10.1002/bdr2.1634
- PMID
- 31863647
- PMCID
- PMC7099603
- NLM abbreviation
- Birth Defects Res
- ISSN
- 2472-1727
- eISSN
- 2472-1727
- Publisher
- Wiley; United States
- Grant note
- U01 DD001035 / CDC HHS\nT42 OH008491 / NIOSH CDC HHS\nU01DD001223 / ACL HHS\nU01 DD001227 / NCBDD CDC HHS\nU01 DD001223 / CDC HHS\nCDP 13-003 / HSRD VA\nU01 DD001035 / NCBDD CDC HHS\nU01 DD001223 / NCBDD CDC HHS\nEP-D-18-001 / EPA
- Language
- English
- Date published
- 02/01/2020
- Academic Unit
- Epidemiology; Biostatistics
- Record Identifier
- 9984066108002771
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