Journal article
Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects
Public health nutrition, Vol.26(3), pp.620-632
05/27/2022
DOI: 10.1017/S1368980022001318
PMCID: PMC9989706
PMID: 35620934
Appears in UI Libraries Support Open Access
Abstract
To explore associations between maternal pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects.
Population-based, case-control study using maternal responses to a dietary assessment and published arsenic concentration estimates in food items to calculate average daily total and inorganic arsenic exposure during the year before pregnancy. Assigning tertiles of total and inorganic arsenic exposure, logistic regression analysis was used to estimate odds ratios for middle and high tertiles, compared to the low tertile.
US National Birth Defects Prevention Study, 1997-2011.
Mothers of 10,446 children without birth defects and 14,408 children diagnosed with a non-cardiac birth defect.
Maternal exposure to total dietary arsenic in the middle and high tertiles was associated with a threefold increase in cloacal exstrophy, with weak positive associations (1.2-1.5) observed either in both tertiles (intercalary limb deficiency) or the high tertile only (encephalocele, glaucoma/anterior chamber defects, bladder exstrophy). Maternal exposure to inorganic arsenic showed mostly weak, positive associations in both tertiles (colonic atresia/stenosis, esophageal atresia, bilateral renal agenesis/hypoplasia, hypospadias, cloacal exstrophy, gastroschisis), or the high (glaucoma/anterior chamber defects, choanal atresia, intestinal atresia stenosis) or middle (encephalocele, intercalary limb deficiency, transverse limb deficiency) tertiles only. The remaining associations estimated were near the null or inverse.
This exploration of arsenic in diet and non-cardiac birth defects produced several positive, but mostly weak associations. Limitations in exposure assessment may have resulted in exposure misclassification. Continued research with improved exposure assessment is recommended to identify if these associations are true signals or chance findings.
Details
- Title: Subtitle
- Pre-pregnancy exposure to arsenic in diet and non-cardiac birth defects
- Creators
- Jonathan Suhl - University of IowaKristin M Conway - University of IowaAnthony Rhoads - Department of Epidemiology, College of Public Health, The University of Iowa, Iowa City, Iowa, USAPeter H Langlois - Department of Epidemiology, Human Genetics, and Environmental Science, University of Texas School of Public Health in Austin, Austin, Texas, USAMarcia L Feldkamp - University of UtahAdrian M Michalski - New York State Department of Health, Bureau of Environmental and Occupational Epidemiology, Albany, New York, USAJacob Oleson - University of IowaAlpa Sidhu - University of IowaVijaya Kancherla - Emory UniversityJohn Obrycki - Boston Children's HospitalMaitreyi Mazumdar - Environmental and Occupational Medicine and Epidemiology Program, Department of Environmental Health, Harvard T.H. Chan School of Public Health, Boston, Massachusetts, USAPaul A Romitti - University of IowaNational Birth Defects Prevention Study
- Resource Type
- Journal article
- Publication Details
- Public health nutrition, Vol.26(3), pp.620-632
- DOI
- 10.1017/S1368980022001318
- PMID
- 35620934
- PMCID
- PMC9989706
- NLM abbreviation
- Public Health Nutr
- ISSN
- 1368-9800
- eISSN
- 1475-2727
- Publisher
- Cambridge University Press
- Language
- English
- Date published
- 05/27/2022
- Academic Unit
- Stead Family Department of Pediatrics; Epidemiology; Biostatistics; Medical Genetics and Genomics
- Record Identifier
- 9984353937702771
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