Journal article
Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study
Osteoarthritis and cartilage, Vol.18(3), pp.323-328
2010
DOI: 10.1016/j.joca.2009.11.002
PMCID: PMC2990960
PMID: 19919856
Abstract
Magnetic resonance imaging (MRI) has greater sensitivity to detect osteoarthritis (OA) damage than radiographs but it is uncertain which MRI findings in early OA are clinically important. We examined MRI abnormalities detected in knees without radiographic OA and their association with incident knee symptoms.
Participants from the Multicenter Osteoarthritis Study (MOST) without frequent knee symptoms (FKS) at baseline were eligible if they also lacked radiographic features of OA at baseline. At 15 months, knees that developed FKS were defined as cases while control knees were drawn from those that remained without FKS. Baseline MRIs were scored at each subregion for cartilage lesions (CARTs); osteophytes (OST); bone marrow lesions (BML) and cysts. We compared cases and controls using marginal logistic regression models, adjusting for age, gender, race, body mass index (BMI), previous injury and clinic site.
36 case knees and 128 control knees were analyzed. MRI damage was common in both cases and controls. The presence of a severe CART (
P
=
0.03), BML (
P
=
0.02) or OST (
P
=
0.02) in the whole knee joint was more common in cases while subchondral cysts did not differ significantly between cases and controls (
P
>
0.1). Case status at 15 months was predicted by baseline damage at only two locations; a BML in the lateral patella (
P
=
0.047) and at the tibial subspinous subregions (
P
=
0.01).
In knees without significant symptoms or radiographic features of OA, MRI lesions of OA in only a few specific locations preceded onset of clinical symptoms and suggest that changes in bone play a role in the early development of knee pain. Confirmation of these findings in other prospective studies of knee OA is warranted.
Details
- Title: Subtitle
- Pre-radiographic MRI findings are associated with onset of knee symptoms: the most study
- Creators
- M.K Javaid - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAJ.A Lynch - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAI Tolstykh - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAA Guermazi - Quantitative Imaging Center (QIC), Department of Radiology, Boston University Medical Center, Boston, MA, USAF Roemer - Quantitative Imaging Center (QIC), Department of Radiology, Boston University Medical Center, Boston, MA, USAP Aliabadi - Quantitative Imaging Center (QIC), Department of Radiology, Boston University Medical Center, Boston, MA, USAC McCulloch - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAJ Curtis - Division of Clinical Immunology and Rheumatology, Department of Medicine, University of Alabama at Birmingham, Birmingham, AL, USAD Felson - Clinical Epidemiology Research and Training Unit, Boston University School of Medicine, Boston, MA, USAN.E Lane - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USAJ Torner - Department of Radiology, Klinikum Augsburg, Augsburg, GermanyM Nevitt - Department of Epidemiology and Biostatistics, University of California, San Francisco, San Francisco, CA, USA
- Resource Type
- Journal article
- Publication Details
- Osteoarthritis and cartilage, Vol.18(3), pp.323-328
- DOI
- 10.1016/j.joca.2009.11.002
- PMID
- 19919856
- PMCID
- PMC2990960
- NLM abbreviation
- Osteoarthritis Cartilage
- ISSN
- 1063-4584
- eISSN
- 1522-9653
- Publisher
- Elsevier Ltd
- Language
- English
- Date published
- 2010
- Academic Unit
- Epidemiology; Surgery; Injury Prevention Research Center; Neurosurgery
- Record Identifier
- 9983995031702771
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