Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents

Andrew Schrepf; Susan K Lutgendorf; Leah M Pyter

doi:10.1016/j.bbi.2015.04.010

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Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents

Journal article

Peer reviewed

Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents

Andrew Schrepf, Susan K Lutgendorf and Leah M Pyter

Brain, behavior, and immunity, Vol.49, pp.1-17

10/2015

DOI: 10.1016/j.bbi.2015.04.010

PMCID: PMC4567396

PMID: 25958011

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Abstract

Cancer patients suffer high levels of affective and cognitive disturbances, which have been attributed to diagnosis-related distress, impairment of quality of life, and side effects of primary treatment. An inflammatory microenvironment is also a feature of the vast majority of solid tumors. However, the ability of tumor-associated biological processes to affect the central nervous system (CNS) has only recently been explored in the context of symptoms of depression and cognitive disturbances. In this review, we summarize the burgeoning evidence from rodent cancer models that solid tumors alter neurobiological pathways and subsequent behavioral processes with relevance to affective and cognitive disturbances reported in human cancer populations. We consider, in parallel, the evidence from human clinical cancer research demonstrating that affective and cognitive disturbances are common in some malignancies prior to diagnosis and treatment. We further consider the underlying neurobiological pathways, including altered neuroinflammation, tryptophan metabolism, prostaglandin synthesis and associated neuroanatomical changes, that are most strongly implicated in the rodent literature and supported by analogous evidence from human cancer populations. We focus on the implications of these findings for behavioral researchers and clinicians, with particular emphasis on methodological issues and areas of future research.

Encephalitis - psychology

Cytokines - metabolism

Humans

Rats

Male

Neoplasms - psychology

Brain - metabolism

Depression - etiology

Mood Disorders - etiology

Neoplasms - complications

Neoplasms - therapy

Animals

Encephalitis - physiopathology

Cognition Disorders - etiology

Encephalitis - metabolism

Inflammation Mediators - metabolism

Female

Encephalitis - complications

Mice

Neoplasms - physiopathology

Disease Models, Animal

Details

Title: Subtitle: Pre-treatment effects of peripheral tumors on brain and behavior: neuroinflammatory mechanisms in humans and rodents
Creators: Andrew Schrepf - Department of Psychology, University of Iowa, Iowa City, IA 52242, USA
Susan K Lutgendorf - Department of Psychology, University of Iowa, Iowa City, IA 52242, USA; Departments of Urology and Obstetrics and Gynecology, University of Iowa, Iowa City, IA 52242, USA
Leah M Pyter - Institute for Behavioral Medicine Research, Departments of Psychiatry and Behavioral Health and Neuroscience, Ohio State University, Columbus, OH 43210, USA. Electronic address: leah.pyter@osumc.edu
Resource Type: Journal article
Publication Details: Brain, behavior, and immunity, Vol.49, pp.1-17
DOI: 10.1016/j.bbi.2015.04.010
PMID: 25958011
PMCID: PMC4567396
NLM abbreviation: Brain Behav Immun
ISSN: 0889-1591
eISSN: 1090-2139
Publisher: Netherlands
Grant note: R01 CA140933 / NCI NIH HHS CA140933 / NCI NIH HHS CA177325 / NCI NIH HHS F31 CA177325 / NCI NIH HHS
Language: English
Date published: 10/2015
Academic Unit: Psychological and Brain Sciences; Iowa Neuroscience Institute; Obstetrics and Gynecology; Urology
Record Identifier: 9984002432002771

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