Journal article
Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity
The Journal of neuroscience, Vol.34(6), pp.2321-2330
02/05/2014
DOI: 10.1523/JNEUROSCI.4547-13.2014
PMCID: PMC3913874
PMID: 24501371
Abstract
Purkinje cells (PCs) of the cerebellar cortex are necessary for controlling movement with precision, but a mechanistic explanation of how the activity of these inhibitory neurons regulates motor output is still lacking. We used an optogenetic approach in awake mice to show for the first time that transiently suppressing spontaneous activity in a population of PCs is sufficient to cause discrete movements that can be systematically modulated in size, speed, and timing depending on how much and how long PC firing is suppressed. We further demonstrate that this fine control of movement kinematics is mediated by a graded disinhibition of target neurons in the deep cerebellar nuclei. Our results prove a long-standing model of cerebellar function and provide the first demonstration that suppression of inhibitory signals can act as a powerful mechanism for the precise control of behavior.
Details
- Title: Subtitle
- Precise Control of Movement Kinematics by Optogenetic Inhibition of Purkinje Cell Activity
- Creators
- Shane A. Heiney - University of PennsylvaniaJinsook Kim - Nanyang Technological UniversityGeorge J Augustine - Institute of Molecular and Cell BiologyJavier F. Medina - University of Pennsylvania
- Resource Type
- Journal article
- Publication Details
- The Journal of neuroscience, Vol.34(6), pp.2321-2330
- DOI
- 10.1523/JNEUROSCI.4547-13.2014
- PMID
- 24501371
- PMCID
- PMC3913874
- NLM abbreviation
- J Neurosci
- ISSN
- 0270-6474
- eISSN
- 1529-2401
- Publisher
- Soc Neuroscience
- Number of pages
- 10
- Grant note
- National Research Foundation of Singapore (Competitive Research Programme grant); National Research Foundation of Korea WCI 2009-003 / Ministry of Education, Science and Technology of Korea; Ministry of Education, Science & Technology (MoST), Republic of Korea R01 MH093727 / National Institutes of Health; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA R01MH093727 / NATIONAL INSTITUTE OF MENTAL HEALTH; United States Department of Health & Human Services; National Institutes of Health (NIH) - USA; NIH National Institute of Mental Health (NIMH) World Class Institute Program of the National Research Foundation of Korea; National Research Foundation of Korea Searle Scholars Program
- Language
- English
- Date published
- 02/05/2014
- Academic Unit
- Iowa Neuroscience Institute; Neuroscience and Pharmacology
- Record Identifier
- 9984622049602771
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